Artículo
Parasite-host glycan interactions during Trypanosoma cruzi infection: trans-Sialidase rides the show
Campetella, Oscar Eduardo
; Buscaglia, Carlos Andres
; Mucci, Juan Sebastián
; Leguizamon, Maria Susana
Fecha de publicación:
05/2020
Editorial:
Elsevier Science
Revista:
Biochimica et Biophysica Acta - Molecular Basis of Disease
ISSN:
0925-4439
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Many important pathogen-host interactions rely on highly specific carbohydrate binding events. In the case of the protozoan Trypanosoma cruzi, the causative agent of Chagas disease, glycointeractions involving sialic acid (SA) residues are pivotal for parasite infectivity, escape from immune surveillance and pathogenesis. Though unable to synthesize SA de novo, T. cruzi displays a unique trans-Sialidase (TS) enzyme, which is able to cleave terminal SA residues from host donor glycoconjugates and transfer them onto parasite surface mucins, thus generating protective/adhesive structures. In addition, this parasite sheds TS into the bloodstream, as a way of modifying the surface SA signature, and thereby the signaling/functional properties of mammalian host target cells on its own advantage. Here, we discuss the pathogenic aspects of T. cruzi TS: its molecular adaptations, the multiplicity of interactions in which it is involved during infections, and the array of novel and appealing targets for intervention in Chagas disease provided by TS-remodeled sialoglycophenotypes.
Palabras clave:
CHAGAS DISEASE
,
PROTEIN TRAFFIC
,
SIALIC ACIDS
,
VIRULENCE FACTORS
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos (IIBIO)
Articulos de INSTITUTO DE INVESTIGACIONES BIOTECNOLOGICAS
Articulos de INSTITUTO DE INVESTIGACIONES BIOTECNOLOGICAS
Articulos(OCA PQUE. CENTENARIO)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA PQUE. CENTENARIO
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA PQUE. CENTENARIO
Citación
Campetella, Oscar Eduardo; Buscaglia, Carlos Andres; Mucci, Juan Sebastián; Leguizamon, Maria Susana; Parasite-host glycan interactions during Trypanosoma cruzi infection: trans-Sialidase rides the show; Elsevier Science; Biochimica et Biophysica Acta - Molecular Basis of Disease; 1866; 5; 5-2020; 1-9; 165692
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