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dc.contributor.author
Sivils, Jeffrey C
dc.contributor.author
Storer, Cheryl L.
dc.contributor.author
Galigniana, Mario Daniel
dc.contributor.author
Cox, Marc B.
dc.date.available
2017-01-05T20:29:39Z
dc.date.issued
2011-08
dc.identifier.citation
Sivils, Jeffrey C; Storer, Cheryl L.; Galigniana, Mario Daniel; Cox, Marc B.; Regulation of steroid hormone receptor function by the 52-kDa FK506-binding protein (FKBP52); Elsevier; Current Opinion In Pharmacology; 11; 4; 8-2011; 314-319
dc.identifier.issn
1471-4892
dc.identifier.uri
http://hdl.handle.net/11336/10890
dc.description.abstract
The large FK506-binding protein FKBP52 has been characterized as an important positive regulator of androgen, glucocorticoid and progesterone receptor signaling pathways. FKBP52 associates with receptor-Hsp90 complexes and is proposed to have roles in both receptor hormone binding and receptor subcellular localization. Data from biochemical and cellular studies have been corroborated in whole animal models as fkbp52-deficient male and female mice display characteristics of androgen, glucocorticoid and/or progesterone insensitivity. FKBP52 receptor specificity and the specific phenotypes displayed by the fkbp52-deficient mice have firmly established FKBP52 as a promising target for the treatment of a variety of hormone-dependent diseases. Recent studies demonstrated that the FKBP52 FK1 domain and the proline-rich loop within this domain are functionally important for FKBP52 regulation of receptor function. Based on these data, efforts are currently underway to target the FKBP52 FK1 domain and the proline-rich loop with small molecule inhibitors.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Receptors
dc.subject
Fkbp52
dc.subject
Steroid
dc.subject
Hsp90
dc.subject.classification
Bioquímica y Biología Molecular
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Regulation of steroid hormone receptor function by the 52-kDa FK506-binding protein (FKBP52)
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-12-30T13:42:59Z
dc.identifier.eissn
1471-4973
dc.journal.volume
11
dc.journal.number
4
dc.journal.pagination
314-319
dc.journal.pais
Reino Unido
dc.journal.ciudad
Oxford
dc.description.fil
Fil: Sivils, Jeffrey C. University Of Texas At El Paso; Estados Unidos
dc.description.fil
Fil: Storer, Cheryl L.. University Of Texas At El Paso; Estados Unidos
dc.description.fil
Fil: Galigniana, Mario Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
dc.description.fil
Fil: Cox, Marc B.. University Of Texas At El Paso; Estados Unidos
dc.journal.title
Current Opinion In Pharmacology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S147148921100049X
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.coph.2011.03.010
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156321/
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