Artículo
Regulation of steroid hormone receptor function by the 52-kDa FK506-binding protein (FKBP52)
Fecha de publicación:
08/2011
Editorial:
Elsevier
Revista:
Current Opinion In Pharmacology
ISSN:
1471-4892
e-ISSN:
1471-4973
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The large FK506-binding protein FKBP52 has been characterized as an important positive regulator of androgen, glucocorticoid and progesterone receptor signaling pathways. FKBP52 associates with receptor-Hsp90 complexes and is proposed to have roles in both receptor hormone binding and receptor subcellular localization. Data from biochemical and cellular studies have been corroborated in whole animal models as fkbp52-deficient male and female mice display characteristics of androgen, glucocorticoid and/or progesterone insensitivity. FKBP52 receptor specificity and the specific phenotypes displayed by the fkbp52-deficient mice have firmly established FKBP52 as a promising target for the treatment of a variety of hormone-dependent diseases. Recent studies demonstrated that the FKBP52 FK1 domain and the proline-rich loop within this domain are functionally important for FKBP52 regulation of receptor function. Based on these data, efforts are currently underway to target the FKBP52 FK1 domain and the proline-rich loop with small molecule inhibitors.
Palabras clave:
Receptors
,
Fkbp52
,
Steroid
,
Hsp90
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Citación
Sivils, Jeffrey C; Storer, Cheryl L.; Galigniana, Mario Daniel; Cox, Marc B.; Regulation of steroid hormone receptor function by the 52-kDa FK506-binding protein (FKBP52); Elsevier; Current Opinion In Pharmacology; 11; 4; 8-2011; 314-319
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