Artículo

Benznidazole levels in blood vary with age in rats

Bulffer, Romina Fernanda; Castro, Jose AlbertoIcon ; Fanelli, Silvia LauraIcon
Fecha de publicación: 05/2011
Editorial: Fundacao Oswaldo Cruz
Revista: Memórias do Instituto Oswaldo Cruz
ISSN: 0074-0276
e-ISSN: 1678-8060
Idioma: Inglés
Tipo de recurso: Artículo publicado

Resumen

Benznidazole (Bz) exhibits toxic side effects in animal studies and clinical use. Reductive metabolism of Bz in liver microsomes modulates the duration of its chemotherapeutic effect and its toxicity. The rate of this metabolism depends on age and is less intense in newborns and youngsters than in adults. In the present study, we determined Bz blood levels in rats of different ages that received Bz intragastrically (100 mg/kg). We developed and validated a high-pressure liquid chromatography with UV detector method for determination of Bz levels in whole blood. Bz levels were significantly higher and persisted for longer periods of time in the blood of young rats when compared to that of adult animals.
Palabras clave: Benznidazole , Rat Blood , Chagas Disease , Hplc
 
Archivos asociados
Thumbnail
 
Tamaño: 386.5Kb
Formato: PDF
.
Licencia
info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/24892
URL: http://ref.scielo.org/nxtdz4
DOI: http://dx.doi.org/10.1590/S0074-02762011000300021
Colecciones
Articulos(ILPLA)
Articulos de INST.DE LIMNOLOGIA "DR. RAUL A. RINGUELET"
Citación
Bulffer, Romina Fernanda; Castro, Jose Alberto; Fanelli, Silvia Laura; Benznidazole levels in blood vary with age in rats; Fundacao Oswaldo Cruz; Memórias do Instituto Oswaldo Cruz; 106; 3; 5-2011; 374-377
Compartir
Altmétricas