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dc.contributor.author
Bulffer, Romina Fernanda  
dc.contributor.author
Castro, Jose Alberto  
dc.contributor.author
Fanelli, Silvia Laura  
dc.date.available
2017-09-21T21:30:19Z  
dc.date.issued
2011-05  
dc.identifier.citation
Bulffer, Romina Fernanda; Castro, Jose Alberto; Fanelli, Silvia Laura; Benznidazole levels in blood vary with age in rats; Fundacao Oswaldo Cruz; Memórias do Instituto Oswaldo Cruz; 106; 3; 5-2011; 374-377  
dc.identifier.issn
0074-0276  
dc.identifier.uri
http://hdl.handle.net/11336/24892  
dc.description.abstract
Benznidazole (Bz) exhibits toxic side effects in animal studies and clinical use. Reductive metabolism of Bz in liver microsomes modulates the duration of its chemotherapeutic effect and its toxicity. The rate of this metabolism depends on age and is less intense in newborns and youngsters than in adults. In the present study, we determined Bz blood levels in rats of different ages that received Bz intragastrically (100 mg/kg). We developed and validated a high-pressure liquid chromatography with UV detector method for determination of Bz levels in whole blood. Bz levels were significantly higher and persisted for longer periods of time in the blood of young rats when compared to that of adult animals.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Fundacao Oswaldo Cruz  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Benznidazole  
dc.subject
Rat Blood  
dc.subject
Chagas Disease  
dc.subject
Hplc  
dc.title
Benznidazole levels in blood vary with age in rats  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2017-09-19T14:35:33Z  
dc.identifier.eissn
1678-8060  
dc.journal.volume
106  
dc.journal.number
3  
dc.journal.pagination
374-377  
dc.journal.pais
Brasil  
dc.journal.ciudad
Rio de Janeiro  
dc.description.fil
Fil: Bulffer, Romina Fernanda. Ministerio de Defensa. Instituto de Investigaciones Científicas y Técnicas para la Defensa; Argentina  
dc.description.fil
Fil: Castro, Jose Alberto. Ministerio de Defensa. Instituto de Investigaciones Científicas y Técnicas para la Defensa; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Fanelli, Silvia Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Limnología "Dr. Raúl A. Ringuelet". Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Instituto de Limnología; Argentina. Ministerio de Defensa. Instituto de Investigaciones Científicas y Técnicas para la Defensa; Argentina  
dc.journal.title
Memórias do Instituto Oswaldo Cruz  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://ref.scielo.org/nxtdz4  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1590/S0074-02762011000300021  

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