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dc.contributor.author
Yim, Kevin C.
dc.contributor.author
Carroll, Clifford J.
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Tuyama, Ana
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Cheshenko, Natalia
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Carlucci, Maria Josefina
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dc.contributor.author
Porter, David D.
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Prince, Gregory A.
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Herold, Betsy C.
dc.date.available
2020-03-18T14:07:34Z
dc.date.issued
2005-12
dc.identifier.citation
Yim, Kevin C.; Carroll, Clifford J.; Tuyama, Ana; Cheshenko, Natalia; Carlucci, Maria Josefina; et al.; The cotton rat provides a novel model to study genital herpes infection and to evaluate preventive strategies; American Society for Microbiology; Journal of Virology; 79; 23; 12-2005; 14632-14639
dc.identifier.issn
0022-538X
dc.identifier.uri
http://hdl.handle.net/11336/99977
dc.description.abstract
Prevention of genital herpes and other sexually transmitted infections (STI) is a critical health priority because of the overwhelming impact on women and infants and the epidemiological association with human immunodeficiency virus (HIV)/AIDS. Small animal models are essential for evaluating strategies for prevention or treatment of STI. Neither the marine nor the guinea pig model of genital herpes fully recapitulates human disease. We demonstrate that herpes simplex virus type 2 (HSV-2) readily infects inbred cotton rats (Sigmodon hispidus). Consistent infection does not require pretreatment with medroxyprogesterone, and primary disease resembles that observed in humans. The animals develop genital lesions and fully recover. During primary infection, viral DNA is also detected in liver, lungs, brain, and kidneys. Clinical self-limited recurrences occur spontaneously but may also be induced by dexamethasone. Pretreatment of cotton rats with PRO 2000 gel, a candidate vaginal microbicide being evaluated in clinical trials to prevent HSV and HIV, protects cotton rats from HSV. Together, these studies suggest that the cotton rat may provide an excellent model to study genital herpes and to evaluate preventive strategies.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Society for Microbiology
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
HERPES
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COTTON RAT
dc.subject.classification
Biología Celular, Microbiología
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
The cotton rat provides a novel model to study genital herpes infection and to evaluate preventive strategies
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-02-13T20:11:32Z
dc.journal.volume
79
dc.journal.number
23
dc.journal.pagination
14632-14639
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Washington DC
dc.description.fil
Fil: Yim, Kevin C.. Virion Systems, Inc.; Estados Unidos
dc.description.fil
Fil: Carroll, Clifford J.. Virion Systems, Inc.; Estados Unidos
dc.description.fil
Fil: Tuyama, Ana. Icahn School of Medicine; Estados Unidos
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Fil: Cheshenko, Natalia. Icahn School of Medicine; Estados Unidos
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Fil: Carlucci, Maria Josefina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
dc.description.fil
Fil: Porter, David D.. Virion Systems, Inc.; Estados Unidos
dc.description.fil
Fil: Prince, Gregory A.. Virion Systems, Inc.; Estados Unidos
dc.description.fil
Fil: Herold, Betsy C.. Icahn School of Medicine; Estados Unidos
dc.journal.title
Journal of Virology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1287570/
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://jvi.asm.org/content/79/23/14632.long
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1128/JVI.79.23.14632-14639.2005
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