Artículo
Expression of the epidermodysplasia verruciformis-associated genes EVER1 and EVER2 is activated by exogenous DNA and inhibited by LMP1 oncoprotein from Epstein-Barr virus
Frecha, Cecilia Ariana
; Chevalier, Sébastien A.; van Uden, Patrick; Rubio, Ivonne; Siouda, Maha; Saidj, Djamel; Cohen, Camille; Lomonte, Patrick; Accardi, Rosita; Tommasino, Massimo
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Fecha de publicación:
01/2015
Editorial:
American Society for Microbiology
Revista:
Journal of Virology
ISSN:
0022-538X
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
EVER1 and EVER2 are mutated in epidermodysplasia verruciformis patients, who are susceptible to human betapapillomavirus (HPV) infection. It is unknown whether their products control the infection of other viruses. Here, we show that the expression of both genes in B cells is activated immediately after Epstein-Barr virus (EBV) infection, whereas at later stages, it is strongly repressed via activation of the NF-κB signaling pathway by latent membrane protein 1 (LMP1). Ectopic expression of EVER1 impairs the ability of EBV to infect B cells.
Palabras clave:
EVER1
,
EVER2
,
EBV-LMP1
,
BCELLS
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Articulos(IBCN)
Articulos de INST.DE BIOLO.CEL.Y NEURCS."PROF.E.DE ROBERTIS"
Articulos de INST.DE BIOLO.CEL.Y NEURCS."PROF.E.DE ROBERTIS"
Citación
Frecha, Cecilia Ariana; Chevalier, Sébastien A.; van Uden, Patrick; Rubio, Ivonne; Siouda, Maha; et al.; Expression of the epidermodysplasia verruciformis-associated genes EVER1 and EVER2 is activated by exogenous DNA and inhibited by LMP1 oncoprotein from Epstein-Barr virus; American Society for Microbiology; Journal of Virology; 89; 2; 1-2015; 1461-1467
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