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dc.contributor.author
Hurley, Michael J.  
dc.contributor.author
Deacon, Robert M. J.  
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Beyer, Katrin  
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Ioannou, Elena  
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Ibañez, Agustin Mariano  
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Teeling, Jessica L.  
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Perez Cogram, Patricia  
dc.date.available
2020-03-13T15:02:32Z  
dc.date.issued
2018-08  
dc.identifier.citation
Hurley, Michael J.; Deacon, Robert M. J.; Beyer, Katrin; Ioannou, Elena; Ibáñez Barassi, Agustín Mariano; et al.; The long-lived Octodon degus as a rodent drug discovery model for Alzheimer's and other age-related diseases; Pergamon-Elsevier Science Ltd; Pharmacology & Therapeutics; 188; 8-2018; 36-44  
dc.identifier.issn
0163-7258  
dc.identifier.uri
http://hdl.handle.net/11336/99471  
dc.description.abstract
Alzheimer's disease (AD) is a multifactorial progressive neurodegenerative disease. Despite decades of research, no disease modifying therapy is available and a change of research objectives and/or development of novel research tools may be required. Much AD research has been based on experimental models using animals with a short lifespan that have been extensively genetically manipulated and do not represent the full spectrum of late-onset AD, which make up the majority of cases. The aetiology of AD is heterogeneous and involves multiple factors associated with the late-onset of the disease like disturbances in brain insulin, oxidative stress, neuroinflammation, metabolic syndrome, retinal degeneration and sleep disturbances which are all progressive abnormalities that could account for many molecular, biochemical and histopathological lesions found in brain from patients dying from AD. This review is based on the long-lived rodent Octodon degus (degu) which is a small diurnal rodent native to South America that can spontaneously develop cognitive decline with concomitant phospho-tau, β-amyloid pathology and neuroinflammation in brain. In addition, the degu can also develop several other conditions like type 2 diabetes, macular and retinal degeneration and atherosclerosis, conditions that are often associated with aging and are often comorbid with AD. Long-lived animals like the degu may provide a more realistic model to study late onset AD.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Pergamon-Elsevier Science Ltd  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
ALZHEIMER'S DISEASE  
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DEGU  
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NEURODEGENERATION  
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NEUROINFLAMMATION  
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OCTODON DEGUS  
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Β-AMYLOID  
dc.subject.classification
Otras Ciencias Biológicas  
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Ciencias Biológicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
The long-lived Octodon degus as a rodent drug discovery model for Alzheimer's and other age-related diseases  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2020-03-10T12:26:05Z  
dc.journal.volume
188  
dc.journal.pagination
36-44  
dc.journal.pais
Países Bajos  
dc.journal.ciudad
Amsterdam  
dc.description.fil
Fil: Hurley, Michael J.. University of Southampton; Reino Unido. Imperial College London; Reino Unido  
dc.description.fil
Fil: Deacon, Robert M. J.. Fraunhofer Institute; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad de Chile; Chile  
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Fil: Beyer, Katrin. Germans Trias Pujol Research Institute; España  
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Fil: Ioannou, Elena. University College London; Estados Unidos. Imperial College London; Reino Unido  
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Fil: Ibáñez Barassi, Agustín Mariano. Australian Research Council; Australia. Universidad Autónoma del Caribe; Colombia. Universidad Adolfo Ibañez; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina  
dc.description.fil
Fil: Teeling, Jessica L.. University of Southampton; Reino Unido  
dc.description.fil
Fil: Perez Cogram, Patricia. Fraunhofer Institute; Alemania. Universidad de Chile; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad Favaloro; Argentina  
dc.journal.title
Pharmacology & Therapeutics  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S016372581830041X  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.pharmthera.2018.03.001