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dc.contributor.author
Curiel, Rosie E.  
dc.contributor.author
Crocco, Elizabeth A.  
dc.contributor.author
Raffo, Arlene  
dc.contributor.author
Guinjoan, Salvador Martín  
dc.contributor.author
Nemeroff, Charles B.  
dc.contributor.author
Penate, Ailyn  
dc.contributor.author
Piña, Daema  
dc.contributor.author
Loewenstein, David A.  
dc.date.available
2020-03-13T14:58:54Z  
dc.date.issued
2018-07  
dc.identifier.citation
Curiel, Rosie E.; Crocco, Elizabeth A.; Raffo, Arlene; Guinjoan, Salvador Martín; Nemeroff, Charles B.; et al.; Failure to Recover from Proactive Semantic Interference Differentiates Amnestic Mild Cognitive Impairment and PreMCI from Normal Aging after Adjusting for Initial Learning Ability; Bentham Science Publishers; Advances in Alzheimer's Disease; 7; 2; 7-2018; 50-61  
dc.identifier.issn
1567-2050  
dc.identifier.uri
http://hdl.handle.net/11336/99469  
dc.description.abstract
Background: There is increasing evidence that the failure to recover from proactive semantic interference (frPSI) may be an early cognitive marker of preclinical Alzheimer’s disease (AD). However, it is unclear whether frPSI effects reflect deficiencies in an individual’s initial learning capacity versus the actual inability to learn new semantically related targets. Objective: The current study was designed to adjust for learning capacity and then to examine the extent to which frPSI, proactive semantic interference (PSI) and retroactive semantic interference (RSI) effects could differentiate between older adults who were cognitively normal (CN), and those diagnosed with either Pre-Mild Cognitive Impairment (PreMCI) or amnestic MCI (aMCI). Methods: We employed the LASSI-L cognitive stress test to examine frPSI, PSI and RSI effects while simultaneously controlling for the participant’s initial learning capacity among 50 CN, 35 aMCI, and 16 PreMCI participants who received an extensive diagnostic work-up. Results: aMCI and PreMCI participants showed greater frPSI deficits (50% and 43.8% respectively) compared to only 14% of CNparticipants. PSI effects were observed for aMCI but not PreMCI participants relative to their CN counterparts. RSI failed to differentiate between any of the study groups. Conclusion: By using participants as their own controls and adjusting for overall learning and memory, it is clear that frPSI deficits occur with much greater frequency in individuals at higher risk for Alzheimer’s disease (AD), and likely reflect a failure of brain compensatory mechanisms.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Bentham Science Publishers  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
ALZHEIMER’S Disease  
dc.subject
MCI  
dc.subject
Semantic Interference  
dc.subject
Memory  
dc.subject.classification
Neurología Clínica  
dc.subject.classification
Medicina Clínica  
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Failure to Recover from Proactive Semantic Interference Differentiates Amnestic Mild Cognitive Impairment and PreMCI from Normal Aging after Adjusting for Initial Learning Ability  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2020-03-10T12:23:39Z  
dc.identifier.eissn
2169-2467  
dc.journal.volume
7  
dc.journal.number
2  
dc.journal.pagination
50-61  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
Oak Park  
dc.description.fil
Fil: Curiel, Rosie E.. University of Miami; Estados Unidos  
dc.description.fil
Fil: Crocco, Elizabeth A.. University of Miami; Estados Unidos  
dc.description.fil
Fil: Raffo, Arlene. University of Miami; Estados Unidos  
dc.description.fil
Fil: Guinjoan, Salvador Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina  
dc.description.fil
Fil: Nemeroff, Charles B.. University of Miami; Estados Unidos  
dc.description.fil
Fil: Penate, Ailyn. Mount Sinai Medical Center; Estados Unidos. University of Miami; Estados Unidos  
dc.description.fil
Fil: Piña, Daema. University of Miami; Estados Unidos  
dc.description.fil
Fil: Loewenstein, David A.. Mount Sinai Medical Center; Estados Unidos. University of Miami; Estados Unidos  
dc.journal.title
Advances in Alzheimer's Disease  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.4236/aad.2018.72004  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.scirp.org/journal/PaperInformation.aspx?PaperID=85502