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dc.contributor.author
Bello, Gonzalo
dc.contributor.author
Aulicino, Paula
dc.contributor.author
Ruchansky, Dora
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Guimarães, Monick L.
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Lopez Galindez, Cecilio
dc.contributor.author
Casado, Concha
dc.contributor.author
Chiparelli, Hector
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Rocco, Carlos Alberto
dc.contributor.author
Mangano, Andrea María Mercedes
dc.contributor.author
Sen, Luisa
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Morgado, Mariza G.
dc.date.available
2020-03-13T13:05:20Z
dc.date.issued
2010-03
dc.identifier.citation
Bello, Gonzalo; Aulicino, Paula; Ruchansky, Dora; Guimarães, Monick L.; Lopez Galindez, Cecilio; et al.; Phylodynamics of HIV-1 Circulating Recombinant Forms 12_BF and 38_BF in Argentina and Uruguay; BioMed Central; Retrovirology; 7; 3-2010; 22-30
dc.identifier.issn
1742-4690
dc.identifier.uri
http://hdl.handle.net/11336/99433
dc.description.abstract
Background: Although HIV-1 CRF12_BF and CRF38_BF are two epidemiologically important recombinant lineages circulating in Argentina and Uruguay, little is known about their population dynamics.Methods: A total of 120 "CRF12_BF-like" and 20 "CRF38_BF-like" pol recombinant sequences collected in Argentina and Uruguay from 1997 to 2009 were subjected to phylogenetic and Bayesian coalescent-based analyses to estimate evolutionary and demographic parameters.Results: Phylogenetic analyses revealed that CRF12_BF viruses from Argentina and Uruguay constitute a single epidemic with multiple genetic exchanges among countries; whereas circulation of the CRF38_BF seems to be confined to Uruguay. The mean estimated substitution rate of CRF12_BF at pol gene (2.5 × 10-3 substitutions/site/year) was similar to that previously described for subtype B. According to our estimates, CRF12_BF and CRF38_BF originated at 1983 (1978-1988) and 1986 (1981-1990), respectively. After their emergence, the CRF12_BF and CRF38_BF epidemics seem to have experienced a period of rapid expansion with initial growth rates of around 1.2 year-1 and 0.9 year-1, respectively. Later, the rate of spread of these CRFs_BF seems to have slowed down since the mid-1990s.Conclusions: Our results suggest that CRF12_BF and CRF38_BF viruses were generated during the 1980s, shortly after the estimated introduction of subtype F1 in South America (~1975-1980). After an initial phase of fast exponential expansion, the rate of spread of both CRFs_BF epidemics seems to have slowed down, thereby following a demographic pattern that resembles those previously reported for the HIV-1 epidemics in Brazil, USA, and Western Europe.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
BioMed Central
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
PHYLODYNAMICS
dc.subject
HIV-I
dc.subject
12_BF
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38_BF
dc.subject.classification
Enfermedades Infecciosas
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Phylodynamics of HIV-1 Circulating Recombinant Forms 12_BF and 38_BF in Argentina and Uruguay
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-03-04T17:33:24Z
dc.journal.volume
7
dc.journal.pagination
22-30
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Bello, Gonzalo. Instituto Oswaldo Cruz; Brasil
dc.description.fil
Fil: Aulicino, Paula. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan". Laboratorio de Biología Celular y Retrovirus; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
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Fil: Ruchansky, Dora. Servicio Nacional de Laboratorios de Salud Publica; Uruguay
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Fil: Guimarães, Monick L.. Instituto Oswaldo Cruz; Brasil
dc.description.fil
Fil: Lopez Galindez, Cecilio. Instituto de Salud Carlos III; España
dc.description.fil
Fil: Casado, Concha. Instituto de Salud Carlos III; España
dc.description.fil
Fil: Chiparelli, Hector. Servicio Nacional de Laboratorios de Salud Publica; Uruguay
dc.description.fil
Fil: Rocco, Carlos Alberto. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan". Laboratorio de Biología Celular y Retrovirus; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Mangano, Andrea María Mercedes. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan". Laboratorio de Biología Celular y Retrovirus; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Sen, Luisa. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan". Laboratorio de Biología Celular y Retrovirus; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Morgado, Mariza G.. Instituto Oswaldo Cruz; Brasil
dc.journal.title
Retrovirology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://retrovirology.biomedcentral.com/articles/10.1186/1742-4690-7-22
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1186/1742-4690-7-22
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