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dc.contributor.author
Fantini, Jacques
dc.contributor.author
Barrantes, Francisco Jose
dc.date.available
2020-03-12T20:50:41Z
dc.date.issued
2018-03
dc.identifier.citation
Fantini, Jacques; Barrantes, Francisco Jose; How membrane lipids control the 3D structure and function of receptors; American Institute of Mathematical Sciences; AIMS Biophysics; 5; 1; 3-2018; 22-35
dc.identifier.issn
2377-9098
dc.identifier.uri
http://hdl.handle.net/11336/99393
dc.description.abstract
The cohabitation of lipids and proteins in the plasma membrane of mammalian cells is controlled by specific biochemical and biophysical rules. Lipids may be either constitutively tightly bound to cell-surface receptors (non-annular lipids) or less tightly attached to the external surface of the protein (annular lipids). The latter are exchangeable with surrounding bulk membrane lipids on a faster time scale than that of non-annular lipids. Not only do non-annular lipids bind to membrane proteins through stereoselective mechanisms, they can also help membrane receptors acquire (or maintain) a functional 3D structure. Cholesterol is the prototype of membrane lipids that finely controls the 3D structure and function of receptors. However, several other lipids such as sphingolipids may also modulate the function of membrane proteins though conformational adjustments. All these concepts are discussed in this review in the light of representative examples taken from the literature.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Institute of Mathematical Sciences
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
CHOLESTEROL
dc.subject
GPCR
dc.subject
HOPANOIDS
dc.subject
ION CHANNELS
dc.subject
LIPID RAFTS
dc.subject
SPHINGOLIPIDS
dc.subject.classification
Biofísica
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
How membrane lipids control the 3D structure and function of receptors
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-03-10T12:26:41Z
dc.journal.volume
5
dc.journal.number
1
dc.journal.pagination
22-35
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Springfield
dc.description.fil
Fil: Fantini, Jacques. Aix Marseille University; Francia
dc.description.fil
Fil: Barrantes, Francisco Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
dc.journal.title
AIMS Biophysics
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3934/biophy.2018.1.22
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.aimspress.com/article/10.3934/biophy.2018.1.22
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