Artículo
In-depth analysis of the origins of HIV type 1 subtype C in South America
Jones, Leandro Roberto
; Dilernia, Darío Alberto
; Manrique, Julieta Marina
; Moretti, Franco; Salomon, Horacio Eduardo
; Gómez Carrillo, Manuel
Fecha de publicación:
10/2009
Editorial:
Mary Ann Liebert
Revista:
Aids Research and Human Retroviruses
ISSN:
0889-2229
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The South American HIV-1 epidemic is characterized by the cocirculation of subtype B and BF recombinant variants. Together with the B and BF genotypes, HIV-1 subtype C (HIV-1C), F1, and several other recombinants have been reported. The epidemiological significance and immune correlates of these "non-B-non-BF" strains circulating in South America are still uncertain and therefore are increasingly attracting the interest of the scientific community. In this study, the South American HIV-1C epidemic was studied using new technologies for the phylogenetic analysis of large datasets. Our results indicate that there is a major clade encompassing most of the South American HIV-1C strains. These analyses also agreed that some strains do not group inside this major clade, suggesting that there could be HIV-1C sequences of different origins circulating in South America. Others have proposed different hypotheses about the origins of HIV-1C strains from South America. This study shows that an exact single origin cannot be determined, a fact that could be attributed to sampling problems, phylogenetic uncertainty, and the shortage of historical and epidemiological data. Currently, the reported data indicate that HIV-1C strains were introduced in Brazil and afterward spread to other regions of South America. By using character optimization on the obtained phylogenetic trees, we observed that Argentina could also be a point in which the HIV-1C epidemic entered South America.
Palabras clave:
HIV
,
Subtype C Epidemic
,
Origin
,
South America
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Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Jones, Leandro Roberto; Dilernia, Darío Alberto; Manrique, Julieta Marina; Moretti, Franco; Salomon, Horacio Eduardo; et al.; In-depth analysis of the origins of HIV type 1 subtype C in South America; Mary Ann Liebert; Aids Research and Human Retroviruses; 25; 10; 10-2009; 951-959
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