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Artículo

Behavioral effects of the combined use of alcohol and energy drinks on alcohol hangover in an experimental mice model

Asorey, Lucas Gustavo; Carbone, Silvia ElenaIcon ; Gonzalez, Bárbara J.; Cutrera, Rodolfo AngelIcon
Fecha de publicación: 03/2018
Editorial: Elsevier Ireland
Revista: Neuroscience Letters
ISSN: 0304-3940
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Neurociencias

Resumen

In last few years it has been a significant increase in the consumption of alcohol combined with energy drink. The aim of this work was to study the effect of this mixture in motor and affective behaviors during an alcohol hangover episode. Male Swiss mice received one of the following treatments: saline + sucrose; saline + energy drink; ethanol + sucrose; ethanol + energy drink. Ethanol dose was 3.8 g/kg BW (i.p.) and energy drink dose was 18 ml/kg BW (gavage) at ZT1 (8 am) (ZT: Zeitgeber time; ZT0: 7 am; lights on). The behavioral tests used were tight rope test to determine motor coordination; hanging wire test to study muscular strength; elevated plus maze and open field tests to evaluate anxiety like-behavior and locomotor activity. Tests were carried out at basal point that matched with lights onset and every 6 h up to 18 h after treatments. Hangover onset was established at ZT7 when blood alcohol concentration (BAC) was almost zero. Our results showed that the mixture of alcohol and energy drink altered significantly motor skills. Specifically, a significant decrease was observed in the performance of the animals in the tightrope and hanging wire tests in groups treated with the mixture of alcohol and energy drink. A significant impairment in the anxiety-like behavior was observed mainly at the beginning of alcohol hangover. These findings suggest that energy drink added to alcohol extends motor disabilities observed during an alcohol hangover episode in comparison with animals that received alcohol alone.
Palabras clave: ALCOHOL , ALCOHOL HANGOVER , ANXIETY-LIKE BEHAVIOR , ENERGY DRINKS , LOCOMOTOR ACTIVITY , MICE , NEUROMUSCULAR COORDINATION
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/99381
DOI: http://dx.doi.org/10.1016/j.neulet.2018.01.030
URL: https://www.sciencedirect.com/science/article/pii/S0304394018300363
Colecciones
Articulos(IFIBIO HOUSSAY)
Articulos de INSTITUTO DE FISIOLOGIA Y BIOFISICA BERNARDO HOUSSAY
Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Asorey, Lucas Gustavo; Carbone, Silvia Elena; Gonzalez, Bárbara J.; Cutrera, Rodolfo Angel; Behavioral effects of the combined use of alcohol and energy drinks on alcohol hangover in an experimental mice model; Elsevier Ireland; Neuroscience Letters; 670; 3-2018; 1-7
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