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dc.contributor.author
Marcott, Pamela F.
dc.contributor.author
Gong, Sheng
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Donthamsetti, Prashant
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Grinnell, Steven G.
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Nelson, Melissa N.
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Newman, Amy H.
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Birnbaumer, Lutz
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Martemyanov, Kirill A.
dc.contributor.author
Javitch, Jonathan A.
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Ford, Christopher P.
dc.date.available
2020-03-12T19:45:37Z
dc.date.issued
2018-05
dc.identifier.citation
Marcott, Pamela F.; Gong, Sheng; Donthamsetti, Prashant; Grinnell, Steven G.; Nelson, Melissa N.; et al.; Regional Heterogeneity of D2-Receptor Signaling in the Dorsal Striatum and Nucleus Accumbens; Cell Press; Neuron; 98; 3; 5-2018; 575-587; e4
dc.identifier.issn
0896-6273
dc.identifier.uri
http://hdl.handle.net/11336/99341
dc.description.abstract
Dopamine input to the dorsal and ventral striatum originates from separate populations of midbrain neurons. Despite differences in afferent inputs and behavioral output, little is known about how dopamine release is encoded by dopamine receptors on medium spiny neurons (MSNs) across striatal subregions. Here we examined the activation of D2 receptors following the synaptic release of dopamine in the dorsal striatum (DStr) and nucleus accumbens (NAc) shell. We found that D2 receptor-mediated synaptic currents were slower in the NAc and this difference occurred at the level of D2-receptor signaling. As a result of preferential coupling to Gαo, we also found that D2 receptors in MSNs demonstrated higher sensitivity for dopamine in the NAc. The higher sensitivity in the NAc was eliminated following cocaine exposure. These results identify differences in the sensitivity and timing of D2-receptor signaling across the striatum that influence how nigrostriatal and mesolimbic signals are encoded across these circuits. Marcott et al. identify that D2 receptors on MSNs differ in their sensitivity and rate of activation between the dorsal striatum and nucleus accumbens. These regional differences in signaling shape how D2 receptors encode dopamine release events in nigrostriatal and mesolimbic circuits.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Cell Press
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ADDICTION
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BASAL GANGLIA
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DOPAMINE
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GPCR
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METABOTROPIC
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SCHIZOPHRENIA
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SENSITIZATION
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STRIATUM
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SYNAPTIC TRANSMISSION
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Bioquímica y Biología Molecular
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Regional Heterogeneity of D2-Receptor Signaling in the Dorsal Striatum and Nucleus Accumbens
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-03-10T12:21:11Z
dc.journal.volume
98
dc.journal.number
3
dc.journal.pagination
575-587; e4
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Marcott, Pamela F.. University of Colorado School of Medicine; Estados Unidos. Case Western Reserve University School of Medicine; Estados Unidos
dc.description.fil
Fil: Gong, Sheng. University of Colorado School of Medicine; Estados Unidos. Case Western Reserve University School of Medicine; Estados Unidos
dc.description.fil
Fil: Donthamsetti, Prashant. Columbia University; Estados Unidos. University of California; Estados Unidos
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Fil: Grinnell, Steven G.. Columbia University. Department of Psychiatry. New York State Psychiatric Institute; Estados Unidos
dc.description.fil
Fil: Nelson, Melissa N.. Columbia University. Department of Psychiatry. New York State Psychiatric Institute; Estados Unidos
dc.description.fil
Fil: Newman, Amy H.. National Institute of Drug Abuse – Intramural Research Program; Estados Unidos
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Fil: Birnbaumer, Lutz. National Institute of Environmental Health Sciences. Neurobiology Laboratory, ; Estados Unidos. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
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Fil: Martemyanov, Kirill A.. The Scripps Research Institute; Estados Unidos
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Fil: Javitch, Jonathan A.. Columbia University. Department of Psychiatry. New York State Psychiatric Institute; Estados Unidos
dc.description.fil
Fil: Ford, Christopher P.. University of Colorado School of Medicine; Estados Unidos. Case Western Reserve University School of Medicine; Estados Unidos
dc.journal.title
Neuron
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.neuron.2018.03.038
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0896627318302447
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