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dc.contributor.author
Barrachina, Isabel  
dc.contributor.author
Neske, Adriana  
dc.contributor.author
Granell, Susana  
dc.contributor.author
Bermejo, Almudena  
dc.contributor.author
Chahboune, Nadia  
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El Aouad, Noureddine  
dc.contributor.author
Alvarez, Olga  
dc.contributor.author
Bardon, Alicia del Valle  
dc.contributor.author
Zafra Polo, M. Carmen  
dc.date.available
2020-03-12T19:25:26Z  
dc.date.issued
2004-09  
dc.identifier.citation
Barrachina, Isabel; Neske, Adriana; Granell, Susana; Bermejo, Almudena; Chahboune, Nadia; et al.; Tucumanin, a β-hydroxy-γ-lactone bistetrahydrofuranic acetogenin from Annona cherimolia, is a potent inhibitor of mitochondrial complex I; Georg Thieme Verlag Kg; Planta Medica; 70; 9; 9-2004; 866-868  
dc.identifier.issn
0032-0943  
dc.identifier.uri
http://hdl.handle.net/11336/99323  
dc.description.abstract
A new β-hydroxy-γ-methyl-γ-lactone bistetrahydrofuranic acetogenin, tucumanin, with the infrequent symmetrical threo/trans/threo/trans/ threo relative configuration at the tetrahydrofuran rings was isolated from Annona cherimolia (Annonaceae) seeds. The inhibitory potency on the mitochondrial complex I of acetogenins with this relative configuration (tucumanin and asimicin) was compared with that shown by the corresponding pairs with an asymmetrical threo/trans/threo/trans/erythro relative configuration (laherradurin/rolliniastatin-2, and itrabin/molvizarin). All these compounds act as selective inhibitors of mitochondrial complex 1 in the 0.18 - 1.55 nM range.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Georg Thieme Verlag Kg  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
β-hydroxy-γ-methyl-γ-lactone  
dc.subject
Annona cherimolia (Annonaceae)  
dc.subject
inhibitory potency  
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mitochondrial complex I  
dc.subject.classification
Otras Ciencias Químicas  
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Ciencias Químicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
Tucumanin, a β-hydroxy-γ-lactone bistetrahydrofuranic acetogenin from Annona cherimolia, is a potent inhibitor of mitochondrial complex I  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2020-03-11T18:26:38Z  
dc.journal.volume
70  
dc.journal.number
9  
dc.journal.pagination
866-868  
dc.journal.pais
Alemania  
dc.journal.ciudad
Stuttgart  
dc.description.fil
Fil: Barrachina, Isabel. Universidad de Valencia; España  
dc.description.fil
Fil: Neske, Adriana. Universidad Nacional de Tucumán; Argentina  
dc.description.fil
Fil: Granell, Susana. Universidad de Valencia; España  
dc.description.fil
Fil: Bermejo, Almudena. Universidad de Valencia; España  
dc.description.fil
Fil: Chahboune, Nadia. Universidad de Valencia; España  
dc.description.fil
Fil: El Aouad, Noureddine. Universidad de Valencia; España  
dc.description.fil
Fil: Alvarez, Olga. Universidad Nacional de Tucumán; Argentina  
dc.description.fil
Fil: Bardon, Alicia del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina. Universidad Nacional de Tucumán; Argentina  
dc.description.fil
Fil: Zafra Polo, M. Carmen. Universidad de Valencia; España  
dc.journal.title
Planta Medica  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1055/s-2004-827237  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-2004-827237