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dc.contributor.author
Monteserin, Johana
dc.contributor.author
Paul, Roxana Elizabeth
dc.contributor.author
Gravina, Elida
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Reniero, Ana
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Hernandez, Teresa
dc.contributor.author
Mazzeo, Eduardo
dc.contributor.author
Togneri, Ana Maria
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Simboli, Norberto
dc.contributor.author
López, Beatriz
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Couvin, David
dc.contributor.author
Rastogi, Nalin
dc.contributor.author
Ritacco, Gloria Viviana
dc.date.available
2020-03-12T00:08:01Z
dc.date.issued
2018-08
dc.identifier.citation
Monteserin, Johana; Paul, Roxana Elizabeth; Gravina, Elida; Reniero, Ana; Hernandez, Teresa; et al.; Genotypic diversity of Mycobacterium tuberculosis in Buenos Aires, Argentina; Elsevier Science; Infection, Genetics and Evolution; 62; 8-2018; 1-7
dc.identifier.issn
1567-1348
dc.identifier.uri
http://hdl.handle.net/11336/99258
dc.description.abstract
Buenos Aires is an overpopulated port city historically inhabited by people of European descent. Together with its broader metropolitan area, the city exhibits medium tuberculosis rates, and receives migrants, mainly from tuberculosis highly endemic areas of Argentina and neighboring countries. This work was aimed to gain insight into the Mycobacterium tuberculosis population structure in two suburban districts of Buenos Aires which are illustrative of the overall situation of tuberculosis in Argentina. The Lineage 4 Euro-American accounted for >99% of the 816 isolates analyzed (one per patient). Frequencies of spoligotype families were T 35.9%, LAM 33.2%, Haarlem 19.5%, S 3.2%, X 1.5%, Ural 0.7%, BOV 0.2%, Beijing 0.2%, and Cameroon 0.2%. Unknown signatures accounted for 5.3% isolates. Of 55 spoligotypes not matching any extant shared international type (SIT) in SITVIT database, 22 fitted into 15 newly-issued SITs. Certain autochthonous South American genotypes were found to be actively evolving. LAM3, which is wild type for RDrio, was the predominant LAM subfamily in both districts and the RDrio signature was rare among autochthonous, newly created, SITs and orphan patterns. Two genotypes that are rarely observed in neighboring countries ̶ SIT2/H2 and SIT159/T1 Tuscany ̶ were conspicuously represented in Argentina. The infrequent Beijing patterns belonged to Peruvian patients. We conclude that the genotype diversity observed reflects the influence of the Hispanic colonization and more recent immigration waves from Mediterranean and neighboring countries. Unlike in Brazil, the RDrio type does not play a major role in the tuberculosis epidemic in Buenos Aires.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
GENOTYPE
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PHYLOGENY
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SOUTH AMERICA
dc.subject.classification
Biología Celular, Microbiología
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Genotypic diversity of Mycobacterium tuberculosis in Buenos Aires, Argentina
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-03-11T13:03:31Z
dc.journal.volume
62
dc.journal.pagination
1-7
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Monteserin, Johana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina
dc.description.fil
Fil: Paul, Roxana Elizabeth. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina
dc.description.fil
Fil: Gravina, Elida. Hospital Interzonal General de Agudos “Dr. Diego Paroissien”; Argentina
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Fil: Reniero, Ana. Hospital Central de San Isidro; Argentina
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Fil: Hernandez, Teresa. Centro de Zooantroponosis de la Matanza; Argentina
dc.description.fil
Fil: Mazzeo, Eduardo. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina
dc.description.fil
Fil: Togneri, Ana Maria. Hospital Interzonal de Agudos Evita; Argentina
dc.description.fil
Fil: Simboli, Norberto. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina
dc.description.fil
Fil: López, Beatriz. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina
dc.description.fil
Fil: Couvin, David. Institut Pasteur de Guadeloupe; Francia
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Fil: Rastogi, Nalin. Institut Pasteur de Guadeloupe; Francia
dc.description.fil
Fil: Ritacco, Gloria Viviana. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina
dc.journal.title
Infection, Genetics and Evolution
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S1567134818301813
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.meegid.2018.04.006
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