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dc.contributor.author
Monteserin, Johana  
dc.contributor.author
Paul, Roxana Elizabeth  
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Gravina, Elida  
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Reniero, Ana  
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Hernandez, Teresa  
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Mazzeo, Eduardo  
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Togneri, Ana Maria  
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Simboli, Norberto  
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López, Beatriz  
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Couvin, David  
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Rastogi, Nalin  
dc.contributor.author
Ritacco, Gloria Viviana  
dc.date.available
2020-03-12T00:08:01Z  
dc.date.issued
2018-08  
dc.identifier.citation
Monteserin, Johana; Paul, Roxana Elizabeth; Gravina, Elida; Reniero, Ana; Hernandez, Teresa; et al.; Genotypic diversity of Mycobacterium tuberculosis in Buenos Aires, Argentina; Elsevier Science; Infection, Genetics and Evolution; 62; 8-2018; 1-7  
dc.identifier.issn
1567-1348  
dc.identifier.uri
http://hdl.handle.net/11336/99258  
dc.description.abstract
Buenos Aires is an overpopulated port city historically inhabited by people of European descent. Together with its broader metropolitan area, the city exhibits medium tuberculosis rates, and receives migrants, mainly from tuberculosis highly endemic areas of Argentina and neighboring countries. This work was aimed to gain insight into the Mycobacterium tuberculosis population structure in two suburban districts of Buenos Aires which are illustrative of the overall situation of tuberculosis in Argentina. The Lineage 4 Euro-American accounted for >99% of the 816 isolates analyzed (one per patient). Frequencies of spoligotype families were T 35.9%, LAM 33.2%, Haarlem 19.5%, S 3.2%, X 1.5%, Ural 0.7%, BOV 0.2%, Beijing 0.2%, and Cameroon 0.2%. Unknown signatures accounted for 5.3% isolates. Of 55 spoligotypes not matching any extant shared international type (SIT) in SITVIT database, 22 fitted into 15 newly-issued SITs. Certain autochthonous South American genotypes were found to be actively evolving. LAM3, which is wild type for RDrio, was the predominant LAM subfamily in both districts and the RDrio signature was rare among autochthonous, newly created, SITs and orphan patterns. Two genotypes that are rarely observed in neighboring countries ̶ SIT2/H2 and SIT159/T1 Tuscany ̶ were conspicuously represented in Argentina. The infrequent Beijing patterns belonged to Peruvian patients. We conclude that the genotype diversity observed reflects the influence of the Hispanic colonization and more recent immigration waves from Mediterranean and neighboring countries. Unlike in Brazil, the RDrio type does not play a major role in the tuberculosis epidemic in Buenos Aires.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier Science  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
GENOTYPE  
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PHYLOGENY  
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SOUTH AMERICA  
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Biología Celular, Microbiología  
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Ciencias Biológicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
Genotypic diversity of Mycobacterium tuberculosis in Buenos Aires, Argentina  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2020-03-11T13:03:31Z  
dc.journal.volume
62  
dc.journal.pagination
1-7  
dc.journal.pais
Países Bajos  
dc.journal.ciudad
Amsterdam  
dc.description.fil
Fil: Monteserin, Johana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina  
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Fil: Paul, Roxana Elizabeth. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina  
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Fil: Gravina, Elida. Hospital Interzonal General de Agudos “Dr. Diego Paroissien”; Argentina  
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Fil: Reniero, Ana. Hospital Central de San Isidro; Argentina  
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Fil: Hernandez, Teresa. Centro de Zooantroponosis de la Matanza; Argentina  
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Fil: Mazzeo, Eduardo. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina  
dc.description.fil
Fil: Togneri, Ana Maria. Hospital Interzonal de Agudos Evita; Argentina  
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Fil: Simboli, Norberto. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina  
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Fil: López, Beatriz. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina  
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Fil: Couvin, David. Institut Pasteur de Guadeloupe; Francia  
dc.description.fil
Fil: Rastogi, Nalin. Institut Pasteur de Guadeloupe; Francia  
dc.description.fil
Fil: Ritacco, Gloria Viviana. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina  
dc.journal.title
Infection, Genetics and Evolution  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S1567134818301813  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.meegid.2018.04.006