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dc.contributor.author
Bachor, Tomás Pedro
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dc.contributor.author
Marquioni Ramella, Melisa Daniela
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dc.contributor.author
Suburo, Angela Maria
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dc.date.available
2020-03-11T19:56:13Z
dc.date.issued
2015-08
dc.identifier.citation
Bachor, Tomás Pedro; Marquioni Ramella, Melisa Daniela; Suburo, Angela Maria; Sitagliptin protects proliferation of neural progenitor cells in diabetic mice; Springer/Plenum Publishers; Metabolic Brain Disease; 30; 4; 8-2015; 885-893
dc.identifier.issn
0885-7490
dc.identifier.uri
http://hdl.handle.net/11336/99196
dc.description.abstract
Sitagliptin (SIT) is a dipeptidyl peptidase-4 (DPP-4) inhibitor that enhances the effects of incretin hormones, such as Glucose-dependent Insulinotropic Peptide (also known as Gastric Inhibitory Polypeptide, GIP) and Glucagon-Like Peptide 1 (GLP-1). We have now evaluated the effect of SIT on proliferation of neural progenitors in diabetic mice. A condition resembling the non-obese type 2 diabetes mellitus (D2) was achieved by a combination of streptozotocin and nicotinamide (NA-STZ), whereas a type 1-like disease (D1) was provoked by STZ without NA. Nondiabetic mice received vehicle injections. Cell proliferation was estimated by bromodeoxyuridine (BrdU) incorporation in two different regions of the subventricular zone (SVZ), the largest reserve of neural stem cells in the adult brain. SIT treatment did not modify the high fasting blood glucose (BG) levels and intraperitoneal glucose tolerance test (IPGTT) of D1 mice. By contrast, in D2 mice, SIT treatment significantly reduced BG and IPGTT. Both D1 and D2 mice showed a substantial reduction of BrdU labeling in the SVZ. Remarkably, SIT treatment improved BrdU labeling in both conditions. Our findings suggest that SIT would protect proliferation of neural progenitor cells even in the presence of non-controlled diabetic alterations.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer/Plenum Publishers
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
DIABETES
dc.subject
GLIPTINS
dc.subject
GLUCAGON-LIKE PEPTIDE 1
dc.subject
NEURAL STEM CELLS
dc.subject
NEUROGENESIS
dc.subject
SUBVENTRICULAR ZONE
dc.subject.classification
Neurociencias
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Sitagliptin protects proliferation of neural progenitor cells in diabetic mice
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-03-03T15:08:00Z
dc.journal.volume
30
dc.journal.number
4
dc.journal.pagination
885-893
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Nueva York
dc.description.fil
Fil: Bachor, Tomás Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina
dc.description.fil
Fil: Marquioni Ramella, Melisa Daniela. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Suburo, Angela Maria. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Metabolic Brain Disease
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs11011-015-9656-2
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s11011-015-9656-2
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