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dc.contributor.author
Daray, Federico Manuel  
dc.contributor.author
Arena, Ángeles R.  
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Armesto, Arnaldo Raúl  
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Rodante, Demián E.  
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Puppo, Soledad  
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Vidjen, Patricia  
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Portela, Alicia  
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Grendas, Leandro  
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Errasti, Andrea Emilse  
dc.date.available
2020-03-10T17:45:58Z  
dc.date.issued
2018-10  
dc.identifier.citation
Daray, Federico Manuel; Arena, Ángeles R.; Armesto, Arnaldo Raúl; Rodante, Demián E.; Puppo, Soledad; et al.; Serotonin transporter gene polymorphism as a predictor of short-term risk of suicide reattempts; Elsevier France-editions Scientifiques Medicales Elsevier; European Psychiatry; 54; 10-2018; 19-26  
dc.identifier.issn
0924-9338  
dc.identifier.uri
http://hdl.handle.net/11336/99038  
dc.description.abstract
Objective: The serotonin-transporter-linked polymorphic region (5-HTTLPR) polymorphisms are associated with suicidal behavior; however, prospective studies are scarce. Herein we aim to determine if 5-HTTLPR polymorphisms predict risk of short-term suicide reattempt in a high-risk suicidal sample. We also explore possible mediators or moderators of this relationship. Methods: A multicenter prospective cohort study was designed to compare data obtained form 136 patients admitted to the emergency department for current suicidal ideation or a recent suicide attempt. Subjects were clinically evaluated, genotyped, and monitored for a new suicide attempt for 6 months. Results: At 6 months of follow up, 21% of the subjects had a new suicide attempt. The frequency of L-allele and L-carrier was higher in reattempters when compared with non-reattempters (55.8% vs. 35.4%, p = 0.01 and 76.9% vs. 54.2%, p = 0.04, respectively). Reattempters also differ from non-reattempters patients with respect to age, history of previous suicide attempts, and age of onset of suicidal behavior. The logistic regression model showed that L-carriers had an odds ratio of 2.8 (95% CI: 1.0–7.6) for reattempts when compared to SS genotype. The adjusted model indicates that this association is not mediated or moderated by impulsivity. Conclusion: The 5-HTTLPR polymorphisms predicted short-term risk of suicidal reattempt independently of age and sex. L-carriers have almost three times more risk of relapse when compared with SS carriers.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier France-editions Scientifiques Medicales Elsevier  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/  
dc.subject
5-HTTLPR  
dc.subject
IMPULSIVITY  
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POLYMORPHISM  
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PREDICTOR  
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SEROTONIN  
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SUICIDE BEHAVIOR  
dc.subject.classification
Psiquiatría  
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Medicina Clínica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Serotonin transporter gene polymorphism as a predictor of short-term risk of suicide reattempts  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2020-03-10T12:22:43Z  
dc.journal.volume
54  
dc.journal.pagination
19-26  
dc.journal.pais
Francia  
dc.description.fil
Fil: Daray, Federico Manuel. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Hospital Neuropsiquiátrico Braulio A. Moyano; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Arena, Ángeles R.. Universidad de Buenos Aires. Facultad de Medicina; Argentina  
dc.description.fil
Fil: Armesto, Arnaldo Raúl. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
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Fil: Rodante, Demián E.. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Hospital Neuropsiquiátrico Braulio A. Moyano; Argentina  
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Fil: Puppo, Soledad. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina  
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Fil: Vidjen, Patricia. Gobierno de la Ciudad de Buenos Aires. Hospital Municipal "José Tiburcio Borda"; Argentina  
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Fil: Portela, Alicia. Gobierno de la Ciudad de Buenos Aires. Hospital Municipal "José Tiburcio Borda"; Argentina  
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Fil: Grendas, Leandro. Universidad de Buenos Aires. Facultad de Medicina; Argentina  
dc.description.fil
Fil: Errasti, Andrea Emilse. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.journal.title
European Psychiatry  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0924933818301366  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.eurpsy.2018.07.001