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dc.contributor.author
Parati, Gianfranco
dc.contributor.author
Agabiti-Rosei, Enrico
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Bakris, George L.
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Bilo, Grzegorz
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Branzi, Giovanna
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Cecchi, Franco
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Chrostowska, Marzena
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De la Sierra, Alejandro
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Domenech, Monica
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Dorobantu, Maria
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Faria, Thays
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Huo, Yong
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Jelakovic, Bojan
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Kahan, Thomas
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Konradi, Alexandra
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Laurent, Stéphane
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Li, Nanfang
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Madan, Kushal
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Mancia, Giuseppe
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McManus, Richard J
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Modesti, Pietro Amedeo
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Ochoa, Juan Eugenio
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Octavio, José Andrés
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Omboni, Stefano
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Palatini, Paolo
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Park, Jeong Bae
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Pellegrini, Dario
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Perl, Sabine
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Podoleanu, Cristian
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Renna, Nicolas Federico
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Rhee, Moo Yong
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Rodilla Sala, Enrique
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Sánchez, Ramiro
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Schmieder, Roland
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Soranna, Davide
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Stergiou, George
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Stojanovic, Milos
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Tsioufis, Konstantinos
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Valsecchi, Maria Grazia
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Veglio, Franco
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Waisman, Gabriel Dario
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Wang, Ji Guang
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Wijnmaalen, Paulina
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Zambon, Antonella
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Zanchetti, Alberto
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Zhang, Yuqing
dc.date.available
2020-03-10T15:02:19Z
dc.date.issued
2018-12
dc.identifier.citation
Parati, Gianfranco; Agabiti-Rosei, Enrico; Bakris, George L.; Bilo, Grzegorz; Branzi, Giovanna; et al.; MASked-unconTrolled hypERtension management based on office BP or on ambulatory blood pressure measurement (MASTER) Study: A randomised controlled trial protocol; BMJ Publishing Group; BMJ Open; 8; 12; 12-2018; 1-10
dc.identifier.issn
2044-6055
dc.identifier.uri
http://hdl.handle.net/11336/99020
dc.description.abstract
Introduction Masked uncontrolled hypertension (MUCH) carries an increased risk of cardiovascular (CV) complications and can be identified through combined use of office (O) and ambulatory (A) blood pressure (BP) monitoring (M) in treated patients. However, it is still debated whether the information carried by ABPM should be considered for MUCH management. Aim of the MASked-unconTrolled hypERtension management based on OBP or on ambulatory blood pressure measurement (MASTER) Study is to assess the impact on outcome of MUCH management based on OBPM or ABPM. Methods and analysis MASTER is a 4-year prospective, randomised, open-label, blinded-endpoint investigation. A total of 1240 treated hypertensive patients from about 40 secondary care clinical centres worldwide will be included -upon confirming presence of MUCH (repeated on treatment OBP <140/90 mm Hg, and at least one of the following: Daytime ABP ≥135/85 mm Hg; night-time ABP ≥120/70 mm Hg; 24 hour ABP ≥130/80 mm Hg), and will be randomised to a management strategy based on OBPM (group 1) or on ABPM (group 2). Patients in group 1 will have OBP measured at 0, 3, 6, 12, 18, 24, 30, 36, 42 and 48 months and taken as a guide for treatment; ABPM will be performed at randomisation and at 12, 24, 36 and 48 months but will not be used to take treatment decisions. Patients randomised to group 2 will have ABPM performed at randomisation and all scheduled visits as a guide to antihypertensive treatment. The effects of MUCH management strategy based on ABPM or on OBPM on CV and renal intermediate outcomes (changing left ventricular mass and microalbuminuria, coprimary outcomes) at 1 year and on CV events at 4 years and on changes in BP-related variables will be assessed. Ethics and dissemination MASTER study protocol has received approval by the ethical review board of Istituto Auxologico Italiano. The procedures set out in this protocol are in accordance with principles of Declaration of Helsinki and Good Clinical Practice guidelines. Results will be published in accordance with the CONSORT statement in a peer-reviewed scientific journal.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
BMJ Publishing Group
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.subject
AMBULATORY BLOOD PRESSURE MONITORING
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HYPERTENSION
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HYPERTENSION MANAGEMENT
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MASKED UNCONTROLLED HYPERTENSION
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OFFICE BLOOD PRESSURE
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TREATED HYPERTENSIVE PATIENTS
dc.subject.classification
Sistemas Cardíaco y Cardiovascular
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
MASked-unconTrolled hypERtension management based on office BP or on ambulatory blood pressure measurement (MASTER) Study: A randomised controlled trial protocol
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-21T20:12:54Z
dc.journal.volume
8
dc.journal.number
12
dc.journal.pagination
1-10
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
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Fil: Parati, Gianfranco. University Of Milan-bicocca, Department Of Medicine; Italia
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Fil: Agabiti-Rosei, Enrico. Azienda Spedali Civili Di Brescia, Department Of Medici; Italia
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Fil: Bakris, George L.. 4-university Of Chicago, Department Of Medicine; Ash; Estados Unidos
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Fil: Bilo, Grzegorz. Irccs Istituto Auxologico Italiano; Italia
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Fil: Branzi, Giovanna. Irccs Istituto Auxologico Italiano; Italia
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Fil: Cecchi, Franco. Università degli Studi di Firenze; Italia
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Fil: Chrostowska, Marzena. Gdanski Uniwersytet Medyczny, ; Rusia
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Fil: De la Sierra, Alejandro. Universidad de Barcelona; España
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Fil: Domenech, Monica. Universidad de Barcelona; España
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Fil: Dorobantu, Maria. Clinical Emergency Hospital Of Bucharest; Rumania
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Fil: Faria, Thays. Irccs Istituto Auxologico Italiano; Italia
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Fil: Huo, Yong. Peking University; China
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Fil: Jelakovic, Bojan. University Of Zagreb School Of Medicine; Croacia
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Fil: Kahan, Thomas. Karolinska Huddinge Hospital. Karolinska Institutet;; Suecia
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Fil: Konradi, Alexandra. Almazov National Medical Research Centre; Rusia
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Fil: Laurent, Stéphane. Universite Paris Descartes; Francia
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Fil: Li, Nanfang. Center Of Hypertension Of The Peoples Hospital; China
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Fil: Madan, Kushal. Sir Ganga Ram Hospital; India
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Fil: Mancia, Giuseppe. University Of Milano - Bicocca; Italia
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Fil: McManus, Richard J. University of Oxford;; Reino Unido
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Fil: Modesti, Pietro Amedeo. Università degli Studi di Firenze;; Italia
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Fil: Ochoa, Juan Eugenio. Irccs Istituto Auxologico Italiano; Italia
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Fil: Octavio, José Andrés. Universidad del Zulia;; Venezuela
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Fil: Omboni, Stefano. Italian Institute Of Telemedicine, ; Italia
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Fil: Palatini, Paolo. Università di Padova; Italia
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Fil: Park, Jeong Bae. Jb Lab And Clinic; Corea del Sur
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Fil: Pellegrini, Dario. Università di Padova;; Italia
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Fil: Perl, Sabine. Medizinische Universität Graz;; Austria
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Fil: Podoleanu, Cristian. University Of Medicine And Pharmacy Of Tîrgu Mureș; Rumania
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Fil: Renna, Nicolas Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.journal.title
BMJ Open
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1136/bmjopen-2017-021038
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