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dc.contributor.author
Losada Eaton, D. M.
dc.contributor.author
Fernandez Miyakawa, Mariano Enrique
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dc.date.available
2020-03-06T20:45:39Z
dc.date.issued
2010-12
dc.identifier.citation
Losada Eaton, D. M.; Fernandez Miyakawa, Mariano Enrique; Clostridium perfringens epsilon toxin inhibits the gastrointestinal transit in mice; Elsevier; Research in Veterinary Science; 89; 3; 12-2010; 404-408
dc.identifier.issn
0034-5288
dc.identifier.uri
http://hdl.handle.net/11336/98995
dc.description.abstract
Epsilon toxin produced by Clostridium perfringens type B and D is a potent toxin that is responsible for a highly fatal enterotoxemia in sheep and goats. In vitro, epsilon toxin produces contraction of the rat ileum as the result of an indirect action, presumably mediated through the autonomic nervous system. To examine the impact of epsilon toxin in the intestinal transit, gastric emptying (GE) and gastrointestinal transit (GIT) were evaluated after intravenous and oral administration of epsilon toxin in mice. Orally administered epsilon toxin produced a delay on the GIT. Inhibition of the small intestinal transit was observed as early as 1 h after the toxin was administered orally but the effects were not observed after 1 week. Epsilon toxin also produced an inhibition in GE and a delay on the GIT when relatively high toxin concentrations were given intravenously. These results indicate that epsilon toxin administered orally or intravenously to mice transitorily inhibits the GIT. The delay in the GIT induced by epsilon toxin could be relevant in the pathogenesis of C. perfringens type B and D enterotoxemia.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
CLOSTRIDIUM PERFRINGENS
dc.subject
ENTEROTOXEMIA
dc.subject
EPSILON TOXIN
dc.subject
INTESTINAL TRANSIT
dc.subject.classification
Ciencias Veterinarias
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dc.subject.classification
Ciencias Veterinarias
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dc.subject.classification
CIENCIAS AGRÍCOLAS
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dc.title
Clostridium perfringens epsilon toxin inhibits the gastrointestinal transit in mice
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-03-04T17:35:02Z
dc.journal.volume
89
dc.journal.number
3
dc.journal.pagination
404-408
dc.journal.pais
Países Bajos
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dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Losada Eaton, D. M.. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Fisiopatogenia; Argentina
dc.description.fil
Fil: Fernandez Miyakawa, Mariano Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Patobiología; Argentina
dc.journal.title
Research in Veterinary Science
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.rvsc.2010.04.006
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0034528810001062
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