Design, construction and application of a neutron shield for the treatment of diffuse lung metastases in rats using BNCT

A model of multiple lung metastases in BDIX rats is under study at CNEA (Argentina) to evaluate the feasibility of BNCT for multiple, non-surgically resectable lung metastases. A practical shielding device that comfortably houses a rat, allowing delivery of a therapeutic, uniform dose in lungs while protecting the body from the neutron beam is presented. Based on the final design obtained by numerical simulations, the shield was constructed, experimentally characterized and recently used in the first in vivo experiment at RA-3.

Palabras clave: COMPUTATIONAL DOSIMETRY , LUNG CANCER , MCNP , MULTIPLE METASTATIC DISEASE , NEUTRON ATTENUATION

Ver el registro completo

Archivos asociados

Tamaño: 849.7Kb

Formato: PDF

Descargar

Licencia

Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)

Identificadores

URI: http://hdl.handle.net/11336/98957

DOI: http://dx.doi.org/10.1016/j.apradiso.2013.12.021

URL: https://www.sciencedirect.com/science/article/pii/S0969804313006210?via%3Dihub

Colecciones

Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL

Citación

Razetti, Agustina; Farías, Rubén Oscar; Thorp, Silvia Inés; Trivillin, Verónica Andrea; Pozzi, E.C.C.; et al.; Design, construction and application of a neutron shield for the treatment of diffuse lung metastases in rats using BNCT; Pergamon-Elsevier Science Ltd; Applied Radiation and Isotopes; 88; 6-2014; 50-54

Altmétricas