Artículo
Macroporous poly(ϵ-caprolactone) with antimicrobial activity obtained by iodine polymerization
de Arruda Almeida, Kleber; de Queiroz, Alvaro Antonio Alencar; Higa, Olga Zazuco; Abraham, Gustavo Abel
; San Román, Julio
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Fecha de publicación:
03/2004
Editorial:
Wiley-liss, Div John Wiley & Sons Inc
Revista:
Journal of Biomedical Materials Research Part A
ISSN:
1549-3296
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The most serious problems usually encountered in the field of implanted medical devices are the infectious morbidity as primary source of mortality. In this work, the synthesis and characterization of a macroporous iodine based sanitizer (iodophor), poly(caprolactone)-iodine, are presented. Characterization methods include nuclear magnetic resonance spectroscopy (1H NMR), gel permeation chromatography (GPC), nitrogen adsorption-desorption and scanning electron microscopy (SEM). The in vitro cytotoxicity to CHO cells in the MTT assay and antimicrobial activities against Escherichia coli and Staphylococcus aureus were examined. The obtained macropore poly(caprolactone)-iodine structures had a rather narrow size distribution. PCL-I iodophor was non-cytotoxic to CHO cells in the MTT assay. Bactericidal activities of the PCL-I were assessed against Escherichia coli and Staphylococcus aureus. The tested PCL-I showed more antimicrobial activity against E. coli and was less active against S. aureus.
Palabras clave:
Antimicrobial activity
,
Poly( -caprolactone)
,
Biological activity
,
Iodophor
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Articulos(INTEMA)
Articulos de INST.DE INV.EN CIENCIA Y TECNOL.MATERIALES (I)
Articulos de INST.DE INV.EN CIENCIA Y TECNOL.MATERIALES (I)
Citación
de Arruda Almeida, Kleber; de Queiroz, Alvaro Antonio Alencar; Higa, Olga Zazuco; Abraham, Gustavo Abel; San Román, Julio; Macroporous poly(ϵ-caprolactone) with antimicrobial activity obtained by iodine polymerization; Wiley-liss, Div John Wiley & Sons Inc; Journal of Biomedical Materials Research Part A; 68A; 3; 3-2004; 473-478
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