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Artículo

Efficacy of a Single High Oxfendazole Dose Against Gastrointestinal Nematodes in Naturally Infected Pigs.

Alvarez, Luis IgnacioIcon ; Saumell, Carlos Alfredo; Fusé, Luis; Moreno, LauraIcon ; Ceballos, LauraIcon ; Domingue, Guilbert; Donadeu, Meritxell; Dungu, Baptiste; Lanusse, Carlos EdmundoIcon
Fecha de publicación: 10/2013
Editorial: Elsevier Science Bv
Revista: Veterinary Parasitology
ISSN: 0304-4017
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ciencias Veterinarias

Resumen

The goal of the current experiment was to assess the clinical efficacy of oxfendazole (OFZ) administered as a single oral dose (30 mg/kg) to pigs naturally parasitized with Ascaris suum, Oesophagostomum spp., Metastrongylus spp. and Trichuris suis. Thirty-six local ecotype piglets were divided into three independent experiments, named I, II and III (n = 12 each), respectively. Each experiment involved two different groups (n = 6): Untreated Control and OFZ treated. Animals were naturally parasitized with A. suum (Experiments I, II and III), Oesophagostomum spp. (Experiments I and II), T. suis (Experiments II and III) and Metastrongylus spp. (Experiment I). Pigs in the treated group received OFZ (Synanthic®, Merial Ltd., 9.06% suspension) orally at 30 mg/kg dose. At five (5) days post-treatment, animals were sacrificed and the clinical efficacy of the OFZ treatment was established following the currently available WAAVP guidelines for a controlled efficacy test. None of the animals involved in this experiment showed any adverse events during the study. OFZ treatment given as a single 30 mg/kg oral dose showed a 100% efficacy against all the nematode parasites present in the three experiments. In conclusion, under the current experimental conditions, OFZ orally administered to naturally parasitized piglets at a single dose of 30 mg/kg was safe and highly efficacious (100%) against adult stages of A. suum, Oesophagostomum spp., T. suis and Metastrongylus spp.
Palabras clave: Oxfendazole , Cerdos , Eficacia
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/988
DOI: https://doi.org/10.1016/j.vetpar.2013.01.003
URL: https://www.sciencedirect.com/science/article/abs/pii/S0304401713000162
Colecciones
Articulos(CIVETAN)
Articulos de CENTRO DE INVESTIGACION VETERINARIA DE TANDIL
Citación
Alvarez, Luis Ignacio; Saumell, Carlos Alfredo; Fusé, Luis; Moreno, Laura; Ceballos, Laura; et al.; Efficacy of a Single High Oxfendazole Dose Against Gastrointestinal Nematodes in Naturally Infected Pigs.; Elsevier Science Bv; Veterinary Parasitology; 194; 10-2013; 70-74
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