Artículo
NMR study on the stabilization and chiral discrimination of sulforaphane enantiomers and analogues by cyclodextrins
Fecha de publicación:
05/2018
Editorial:
Elsevier
Revista:
Carbohydrate Polymers
ISSN:
0144-8617
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Sulforaphane (SFN), a phytochemical isolated from broccoli, is an important antitumoral compound with additional beneficial effect on other important diseases. However, the chemical instability of SFN has hampered its clinical use. In order to circumvent this problem, we report the first comparative study on the inclusion complexes of SFN and SFN homologues with different cyclodextrins by NMR spectroscopy. From this study it has been shown that α-CD is the most indicated cyclodextrin for the stabilization of SFN and SFN homologues, and that the highest affinity constant is that of the isothiocyanate obtained from the wasabi. Furthermore, the study of the inclusion complexes of α-CD and the non-natural SFN and analogues with S absolute configuration at sulfur shows for the first time that α-CD is able to discriminate between the two enantiomers, with the natural R enantiomers forming the inclusion complexes with higher affinity.
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Recio, Rocío; Elhalem, Eleonora; Benito, Juan Andrés; Fernández, Inmaculada; Khiar, Noureddine; NMR study on the stabilization and chiral discrimination of sulforaphane enantiomers and analogues by cyclodextrins; Elsevier; Carbohydrate Polymers; 187; 5-2018; 118-125
Compartir
Altmétricas