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dc.contributor.author
Davies Sala, Carol Giselle
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Soler Bistue, Alfonso J. C.
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Bonomo, Robert A.
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Zorreguieta, Angeles
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Tolmasky, Marcelo E.
dc.date.available
2016-12-20T21:00:07Z
dc.date.issued
2015-09
dc.identifier.citation
Davies Sala, Carol Giselle; Soler Bistue, Alfonso J. C.; Bonomo, Robert A.; Zorreguieta, Angeles; Tolmasky, Marcelo E.; External guide sequence technology: a path to development of novel antimicrobial therapeutics; New York Academy of Sciences; Annals Of The New York Academy Of Sciences.; 1354; 9-2015; 98-110
dc.identifier.issn
0077-8923
dc.identifier.uri
http://hdl.handle.net/11336/9863
dc.description.abstract
RNase P is a ribozyme originally identified for its role in maturation of tRNAs by cleavage of precursor tRNAs (pre-tRNAs) at the 5'-end termini. RNase P is a ribonucleoprotein consisting of a catalytic RNA molecule and, depending on the organism, one or more cofactor proteins. The site of cleavage of a pre-tRNA is identified by its tertiary structure; and any RNA molecule can be cleaved by RNase P as long as the RNA forms a duplex that resembles the regional structure in the pre-tRNA. When the antisense sequence that forms the duplex with the strand that is subsequently cleaved by RNase P is in a separate molecule, it is called an external guide sequence (EGS). These fundamental observations are the basis for EGS technology, which consists of inhibiting gene expression by utilizing an EGS that elicits RNase P-mediated cleavage of a target mRNA molecule. EGS technology has been used to inhibit expression of a wide variety of genes, and may help development of novel treatments of diseases, including multidrug-resistant bacterial and viral infections.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
New York Academy of Sciences
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Antimicrobianos
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Nuevas Terapias
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Tecnología Antisentido
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Ribozima P
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Bioquímica y Biología Molecular
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
External guide sequence technology: a path to development of novel antimicrobial therapeutics
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-12-16T17:26:48Z
dc.journal.volume
1354
dc.journal.pagination
98-110
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Davies Sala, Carol Giselle. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. California State University Fullerton; Estados Unidos. Fundación Instituto Leloir; Argentina
dc.description.fil
Fil: Soler Bistue, Alfonso Jc. Fundación Instituto Leloir; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. California State University Fullerton; Estados Unidos
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Fil: Bonomo, Robert A.. Case Western Reserve University School of Medicine; Estados Unidos
dc.description.fil
Fil: Zorreguieta, Angeles. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Fundación Instituto Leloir; Argentina
dc.description.fil
Fil: Tolmasky, Marcelo E.. California State University; Estados Unidos
dc.journal.title
Annals Of The New York Academy Of Sciences.
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/nyas.12755/abstract
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info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/nyas.12755
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info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600001/