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dc.contributor.author
Rojas García, Pedro P.
dc.contributor.author
Recabarren, Mónica
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dc.contributor.author
Sarabia, Luis
dc.contributor.author
Schön, Jennifer
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Gabler, Christoph
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Einspanier, Ralf
dc.contributor.author
Maliqueo, Manuel
dc.contributor.author
Sir Petermann, Teresa
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dc.contributor.author
Rey, Rodolfo Alberto
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dc.contributor.author
Recabarren, Sergio E.
dc.date.available
2020-03-02T18:05:48Z
dc.date.issued
2010-12
dc.identifier.citation
Rojas García, Pedro P.; Recabarren, Mónica; Sarabia, Luis; Schön, Jennifer; Gabler, Christoph; et al.; Prenatal testosterone excess alters Sertoli and germ cell number and testicular FSH receptor expression in rams; American Physiological Society; American Journal Of Physiology-endocrinology And Metabolism; 299; 6; 12-2010; 1-9
dc.identifier.issn
0193-1849
dc.identifier.uri
http://hdl.handle.net/11336/98631
dc.description.abstract
Exposure to excess testosterone (T) during fetal life has a profound impact on the metabolic and reproductive functions in the female's postnatal life. However, less is known about the effects of excess testosterone in males. The aim of the present study was to evaluate the impact (consequences) of an excess of T during fetal development on mature male testis. The testicular evaluation was by histological analysis and by determination of mRNA expression of the FSH receptor (FSH-R), transforming growth factor-β type I receptor (TβR-I), and two members of the TGF-β superfamily, transforming growth factor-β3 (TGFβ3) and anti-Müllerian hormone (AMH) in males born to mothers receiving an excess of T during pregnancy. At 42 wk of age, postpubertal males born to mothers treated with 30 mg of T propionate twice weekly from day 30 to 90, followed by 40 mg of T propionate from day 90 to 120 of pregnancy (T males), showed higher concentrations of FSH in response to a GnRH analog, a higher number of Sertoli cells/seminiferous tubule cross-section, and a lower number of germ cells/tubules (P < 0.05) than control males (C males) born to mothers treated with the vehicle. The mRNA expression of FSH-R and of TβR-I was higher in T males compared with C males (P < 0.05). Moreover, in T males, AMH expression level correlated negatively with the expression level of TGFβ3. In C males, this latter correlation was not observed. These results suggest that prenatal exposure to an excess of T can negatively modify some histological and molecular characteristics of the mature testis.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Physiological Society
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
FETAL PROGRAMMING
dc.subject
FOLLICLE-STIMULATING HORMONE
dc.subject.classification
Biología Reproductiva
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Prenatal testosterone excess alters Sertoli and germ cell number and testicular FSH receptor expression in rams
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-02-07T13:48:01Z
dc.journal.volume
299
dc.journal.number
6
dc.journal.pagination
1-9
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Bethesda
dc.description.fil
Fil: Rojas García, Pedro P.. Universidad de Concepción; Chile
dc.description.fil
Fil: Recabarren, Mónica. Universidad de Concepción; Chile
dc.description.fil
Fil: Sarabia, Luis. Universidad de Chile; Chile
dc.description.fil
Fil: Schön, Jennifer. Freie Universität; Alemania
dc.description.fil
Fil: Gabler, Christoph. Freie Universität; Alemania
dc.description.fil
Fil: Einspanier, Ralf. Freie Universität; Alemania
dc.description.fil
Fil: Maliqueo, Manuel. Universidad de Chile; Chile
dc.description.fil
Fil: Sir Petermann, Teresa. Universidad de Chile; Chile
dc.description.fil
Fil: Rey, Rodolfo Alberto. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Biología Celular e Histología; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina
dc.description.fil
Fil: Recabarren, Sergio E.. Universidad de Concepción; Chile
dc.journal.title
American Journal Of Physiology-endocrinology And Metabolism
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1152/ajpendo.00032.2010
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://journals.physiology.org/doi/full/10.1152/ajpendo.00032.2010#ref-list-1
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