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dc.contributor.author
Aranda, Federico
dc.contributor.author
Udry, Sebastián
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Perés Wingeyer, Silvia
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Amshoff, Lea Christina
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Bogdanova, Nadja
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Wieacker, Peter
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Latino, José Omar
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Markoff, Arseni
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de Larrañaga, Gabriela Fernanda
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dc.date.available
2020-02-27T22:38:03Z
dc.date.issued
2018-03
dc.identifier.citation
Aranda, Federico; Udry, Sebastián; Perés Wingeyer, Silvia; Amshoff, Lea Christina; Bogdanova, Nadja; et al.; Maternal carriers of the ANXA5 M2 haplotype are exposed to a greater risk for placenta-mediated pregnancy complications; Springer/Plenum Publishers; Journal of Assisted Reproduction and Genetics; 35; 5; 3-2018; 921-928
dc.identifier.issn
1058-0468
dc.identifier.uri
http://hdl.handle.net/11336/98552
dc.description.abstract
Purpose Annexin A5 (ANXA5) is a protein abundantly expressed in normal placenta where it contributes to the healthy outcome of a pregnancy. Lower ANXA5 levels have been observed in M2/ANXA5 haplotype carrying chorion. Consequently, this study aimed to assess the potential association of M2 maternal carrier status with the risk of recurrent pregnancy loss (RPL), the timing of miscarriages, and other obstetric complications, for the first time in a population from Latin America. Methods This study was designed as a prospective recruitment of RPL patients with post hoc analysis. The distribution of the M2/ANXA5 haplotype was compared between a group of 229 Argentine women with RPL and 100 parous controls, and was further analyzed in subgroups of patients stratified according to the timing of miscarriages and in relation to other obstetric complications. Results No significant differences were found in the distribution of M2 haplotype among either RPL patients or the subgroups with embryonic, early fetal, or late fetal losses compared to parous controls. Notwithstanding, maternal M2/ANXA5 was found to be independently associated with a higher risk of suffering intrauterine growth restriction (IUGR) and/or preeclampsia (PE). Simultaneously, the presence of inherited and/or acquired thrombophilia also proved to be an independent risk factor for these. Conclusions The association found between the maternal carriage of the M2/ANXA5 haplotype and an elevated risk of IUGR and/or PE supports the hypothesis that carrier status of this haplotype and the consequently reduced placental ANXA5 expression might be responsible, at least partially, for the onset of these gestational vascular complications.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer/Plenum Publishers
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ANNEXIN A5
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IUGR
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M2/ANXA5
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PRE-ECLAMPSIA
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RECURRENT PREGNANCY LOSS
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RISK FACTOR
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Obstetricia y Ginecología
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Medicina Clínica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Maternal carriers of the ANXA5 M2 haplotype are exposed to a greater risk for placenta-mediated pregnancy complications
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-02-26T15:00:49Z
dc.journal.volume
35
dc.journal.number
5
dc.journal.pagination
921-928
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Aranda, Federico. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; Argentina
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Fil: Udry, Sebastián. Hospital General de Agudos"Dr Carlos G. Durand"; Argentina
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Fil: Perés Wingeyer, Silvia. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; Argentina
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Fil: Amshoff, Lea Christina. University Hospital Munster; Alemania
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Fil: Bogdanova, Nadja. University Hospital Munster; Alemania
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Fil: Wieacker, Peter. University Hospital Munster; Alemania
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Fil: Latino, José Omar. Hospital General de Agudos "Carlos G. Durand"; Argentina
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Fil: Markoff, Arseni. University Hospital Munster; Alemania
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Fil: de Larrañaga, Gabriela Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; Argentina
dc.journal.title
Journal of Assisted Reproduction and Genetics
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://link.springer.com/10.1007/s10815-018-1142-4
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s10815-018-1142-4
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