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dc.contributor.author
Byrne, Alana Brooke
dc.contributor.author
Gutierrez, Francisco Guillermo
dc.contributor.author
Bruno, Agostina Alejandra
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Cordoba, María Teresa
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Bono, María M.
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Polack, Fernando Pedro
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Talarico, Laura Beatriz
dc.contributor.author
Quipildor, Marcelo Omar
dc.date.available
2020-02-27T20:53:52Z
dc.date.issued
2018-02
dc.identifier.citation
Byrne, Alana Brooke; Gutierrez, Francisco Guillermo; Bruno, Agostina Alejandra; Cordoba, María Teresa; Bono, María M.; et al.; Age-associated differences in clinical manifestations and laboratory parameters during a dengue virus type 4 outbreak in Argentina; Wiley-liss, Div John Wiley & Sons Inc; Journal of Medical Virology; 90; 2; 2-2018; 197-203
dc.identifier.issn
0146-6615
dc.identifier.uri
http://hdl.handle.net/11336/98544
dc.description.abstract
Infection by any of the four dengue virus (DENV) serotypes produces a wide spectrum of clinical illness in humans. Differences in clinical manifestation and severity have been associated with secondary heterologous infection, patient age, and virus serotype. In this context, this retrospective study sought to analyze the presentation of dengue in patients during the 2014 DENV-4 outbreak affecting the City of Orán, Salta Province, Argentina. Demographic data, clinical manifestations, and laboratory abnormalities of laboratory-confirmed dengue patients were compared between age groups and between patients with and without warning signs. Of 301 patients with laboratory-confirmed dengue, 37.9% presented dengue with warning signs. Although nearly half of all patients had secondary DENV infections, no severe dengue cases, or deaths were reported. Furthermore, no association was found between incidence of warning signs and pre-existing immunity to DENV. Pediatric patients were least likely to present warning signs and showed significantly decreased risk of fever, retro-orbital pain, arthalgia, diarrhea and thrombocytopenia, and higher risk of rash compared to older patients. Female patients of all ages were also at higher risk of developing several symptoms. The characterization of DENV-4 infection in humans, a DENV serotype recently reported in Argentina, revealed differences in clinical manifestations, laboratory parameters and the presence/absence of warning signs based on age group. Further investigation of these age-related differences should contribute to better assessment of dengue disease in at risk populations.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley-liss, Div John Wiley & Sons Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
AGE-RELATED DIFFERENCES
dc.subject
DENGUE VIRUS
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DISEASE OUTCOMES
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EPIDEMIOLOGY
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PEDIATRIC POPULATION
dc.subject.classification
Inmunología
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Age-associated differences in clinical manifestations and laboratory parameters during a dengue virus type 4 outbreak in Argentina
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-02-26T14:57:49Z
dc.journal.volume
90
dc.journal.number
2
dc.journal.pagination
197-203
dc.journal.pais
Estados Unidos
dc.journal.title
Journal of Medical Virology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.24952
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/jmv.24952