Artículo

Bactericidal and Hemolytic Activities of Synthetic Peptides Derived from Granulysin

Siano, Alvaro SebastíanIcon ; Tonarelli, Georgina Guadalupe; Imaz, María Susana; Perín, Juan Carlos; Ruggeri, María Natalia; Lopez, M.; Santi, Maria Noemi; Zerbini, Elsa Virginia
Fecha de publicación: 04/2010
Editorial: Bentham Science Publishers
Revista: Protein and Peptide Letters
ISSN: 0929-8665
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

Granulysin is a human polypeptide produced by cytolytic cells active against a broad range of microbes. Three peptides covering the regions 25-50 (Gr-1 and Gr-2) and 39-62 (Gr-3) of granulysin were synthesized, and their in vitro activity against Mycobacterium tuberculosis was evaluated. The most active peptide was Gr-1C, containing a disulphide bridge, with Minimal Inhibitory Concentration value of 10.1 μM. In concentrations of up to 50 μM, Gr-1 and Gr2 didn't exceed 30% of hemolysis.
Palabras clave: ANTIMICROBIAL PEPTIDES , GRANULYSIN , MYCOBACTERIUM TUBERCULOSIS , SYNTHETIC PEPTIDES
 
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/98388
URL: http://www.benthamdirect.org/pages/content.php?PPL/2010/00000017/00000004/0017E.
DOI: http://dx.doi.org/10.2174/092986610790963555
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Articulos(CCT - SANTA FE)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - SANTA FE
Citación
Siano, Alvaro Sebastían; Tonarelli, Georgina Guadalupe; Imaz, María Susana; Perín, Juan Carlos; Ruggeri, María Natalia; et al.; Bactericidal and Hemolytic Activities of Synthetic Peptides Derived from Granulysin; Bentham Science Publishers; Protein and Peptide Letters; 17; 4; 4-2010; 517-521
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