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dc.contributor.author
Codner, Ethel
dc.contributor.author
Iñiguez, Germán
dc.contributor.author
Hernández, Isabel M.
dc.contributor.author
Lopez, Patricia
dc.contributor.author
Rhumie, Hana K.
dc.contributor.author
Villarroel, Claudio
dc.contributor.author
Rey, Rodolfo Alberto
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dc.date.available
2020-02-21T21:35:57Z
dc.date.issued
2011-01
dc.identifier.citation
Codner, Ethel; Iñiguez, Germán; Hernández, Isabel M.; Lopez, Patricia; Rhumie, Hana K.; et al.; Elevated anti-Müllerian hormone (AMH) and inhibin B levels in prepubertal girls with type 1 diabetes mellitus; Wiley Blackwell Publishing, Inc; Clinical Endocrinology; 74; 1; 1-2011; 73-78
dc.identifier.issn
0300-0664
dc.identifier.uri
http://hdl.handle.net/11336/98365
dc.description.abstract
Objective Elevated anti-Müllerian hormone (AMH) and adrenal androgen levels have been observed during childhood in girls at risk of developing polycystic ovarian syndrome (PCOS). The aim of this study was to evaluate ovarian function and adrenal steroid levels in prepubertal girls with type 1 diabetes mellitus (T1D). Design Cross-sectional study. Patients/Measurements We evaluated hormonal and ultrasonographic characteristics in girls with T1D (N = 73) and compared them to characteristics found in a control group of healthy girls (N = 86). Data are reported as geometric means (95% CI). Results Prepubertal girls with T1D had higher levels of AMH (29·1 pmol/l (23·2-36·3) vs 20·9 pmol/l (16·6-26·1), P = 0·038), inhibin B (arithmetic mean: 16·7 pg/ml (11·6-21·7) vs 11·7 pg/ml (10·0-13·5), P = 0·044) and dehydroepiandrosterone sulphate (DHEAS) (0·3 nmol/l (0·2-0·6) vs 0·2 nmol/l (0·1-0·3)) than controls (P = 0·045). During puberty, decreasing AMH levels were observed in girls with T1D only (P < 0·0001). Girls with T1D in Tanner stages 4-5 had lower AMH levels than their paired healthy controls (10·1 pmol/l (7·4-13·9) vs 15·7 pmol/l (11·6-21·3), respectively, P = 0·047). Conclusions Our observations indicate that prepubertal girls with T1D may exhibit similar endocrine findings to those of other girls at risk of developing PCOS. The elevated levels of AMH and inhibin B suggest that higher numbers of follicles are present in the ovary during childhood in these patients and that insulin treatment may act as a local growth factor. In addition, AMH levels differed in prepubertal and pubertal girls, suggesting that the effect of T1D on ovarian folliculogenesis changes once gonadotrophin levels rise during puberty.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
AMH
dc.subject.classification
Endocrinología y Metabolismo
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dc.subject.classification
Medicina Clínica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Elevated anti-Müllerian hormone (AMH) and inhibin B levels in prepubertal girls with type 1 diabetes mellitus
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-02-07T13:49:41Z
dc.journal.volume
74
dc.journal.number
1
dc.journal.pagination
73-78
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Codner, Ethel. Universidad de Chile; Chile
dc.description.fil
Fil: Iñiguez, Germán. Universidad de Chile; Chile
dc.description.fil
Fil: Hernández, Isabel M.. Universidad de Chile; Chile
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Fil: Lopez, Patricia. Universidad de Chile; Chile. Hospital Clinico San Borja Arriarán; Chile
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Fil: Rhumie, Hana K.. Hospital Sótero del Río; Chile
dc.description.fil
Fil: Villarroel, Claudio. Universidad de Chile; Chile
dc.description.fil
Fil: Rey, Rodolfo Alberto. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Clinical Endocrinology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2265.2010.03887.x
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/j.1365-2265.2010.03887.x
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