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dc.contributor.author
Codner, Ethel  
dc.contributor.author
Iñiguez, Germán  
dc.contributor.author
Hernández, Isabel M.  
dc.contributor.author
Lopez, Patricia  
dc.contributor.author
Rhumie, Hana K.  
dc.contributor.author
Villarroel, Claudio  
dc.contributor.author
Rey, Rodolfo Alberto  
dc.date.available
2020-02-21T21:35:57Z  
dc.date.issued
2011-01  
dc.identifier.citation
Codner, Ethel; Iñiguez, Germán; Hernández, Isabel M.; Lopez, Patricia; Rhumie, Hana K.; et al.; Elevated anti-Müllerian hormone (AMH) and inhibin B levels in prepubertal girls with type 1 diabetes mellitus; Wiley Blackwell Publishing, Inc; Clinical Endocrinology; 74; 1; 1-2011; 73-78  
dc.identifier.issn
0300-0664  
dc.identifier.uri
http://hdl.handle.net/11336/98365  
dc.description.abstract
Objective Elevated anti-Müllerian hormone (AMH) and adrenal androgen levels have been observed during childhood in girls at risk of developing polycystic ovarian syndrome (PCOS). The aim of this study was to evaluate ovarian function and adrenal steroid levels in prepubertal girls with type 1 diabetes mellitus (T1D). Design Cross-sectional study. Patients/Measurements We evaluated hormonal and ultrasonographic characteristics in girls with T1D (N = 73) and compared them to characteristics found in a control group of healthy girls (N = 86). Data are reported as geometric means (95% CI). Results Prepubertal girls with T1D had higher levels of AMH (29·1 pmol/l (23·2-36·3) vs 20·9 pmol/l (16·6-26·1), P = 0·038), inhibin B (arithmetic mean: 16·7 pg/ml (11·6-21·7) vs 11·7 pg/ml (10·0-13·5), P = 0·044) and dehydroepiandrosterone sulphate (DHEAS) (0·3 nmol/l (0·2-0·6) vs 0·2 nmol/l (0·1-0·3)) than controls (P = 0·045). During puberty, decreasing AMH levels were observed in girls with T1D only (P < 0·0001). Girls with T1D in Tanner stages 4-5 had lower AMH levels than their paired healthy controls (10·1 pmol/l (7·4-13·9) vs 15·7 pmol/l (11·6-21·3), respectively, P = 0·047). Conclusions Our observations indicate that prepubertal girls with T1D may exhibit similar endocrine findings to those of other girls at risk of developing PCOS. The elevated levels of AMH and inhibin B suggest that higher numbers of follicles are present in the ovary during childhood in these patients and that insulin treatment may act as a local growth factor. In addition, AMH levels differed in prepubertal and pubertal girls, suggesting that the effect of T1D on ovarian folliculogenesis changes once gonadotrophin levels rise during puberty.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Wiley Blackwell Publishing, Inc  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
AMH  
dc.subject.classification
Endocrinología y Metabolismo  
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Medicina Clínica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Elevated anti-Müllerian hormone (AMH) and inhibin B levels in prepubertal girls with type 1 diabetes mellitus  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2020-02-07T13:49:41Z  
dc.journal.volume
74  
dc.journal.number
1  
dc.journal.pagination
73-78  
dc.journal.pais
Reino Unido  
dc.journal.ciudad
Londres  
dc.description.fil
Fil: Codner, Ethel. Universidad de Chile; Chile  
dc.description.fil
Fil: Iñiguez, Germán. Universidad de Chile; Chile  
dc.description.fil
Fil: Hernández, Isabel M.. Universidad de Chile; Chile  
dc.description.fil
Fil: Lopez, Patricia. Universidad de Chile; Chile. Hospital Clinico San Borja Arriarán; Chile  
dc.description.fil
Fil: Rhumie, Hana K.. Hospital Sótero del Río; Chile  
dc.description.fil
Fil: Villarroel, Claudio. Universidad de Chile; Chile  
dc.description.fil
Fil: Rey, Rodolfo Alberto. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.journal.title
Clinical Endocrinology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2265.2010.03887.x  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/j.1365-2265.2010.03887.x