Artículo
Signaling pathways involved in renal oxidative injury: role of the vasoactive peptides and the renal dopaminergic system
Rukavina Mikusic, Natalia Lucía
; Kravetz, Maria Cecilia; Kouyoumdzian, Nicolás Martín
; Della Penna, S. L.; Roson, Maria Ines
; Fernandez, Belisario Enrique
; Choi, Marcelo Roberto
Fecha de publicación:
11/2014
Editorial:
Hindawi Publishing Corporation
Revista:
Journal of Signal Transduction
ISSN:
2090-1739
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The physiological hydroelectrolytic balance and the redox steady state in the kidney are accomplished by an intricate interaction between signals from extrarenal and intrarenal sources and between antinatriuretic and natriuretic factors. Angiotensin II, atrial natriuretic peptide and intrarenal dopamine play a pivotal role in this interactive network. The balance between endogenous antioxidant agents like the renal dopaminergic system and atrial natriuretic peptide, by one side, and the prooxidant effect of the renin angiotensin system, by the other side, contributes to ensuring the normal function of the kidney. Different pathological scenarios, as nephrotic syndrome and hypertension, where renal sodium excretion is altered, are associated with an impaired interaction between two natriuretic systems as the renal dopaminergic system and atrial natriuretic peptide that may be involved in the pathogenesis of renal diseases. The aim of this review is to update and comment the most recent evidences about the intracellular pathways involved in the relationship between endogenous antioxidant agents like the renal dopaminergic system and atrial natriuretic peptide and the prooxidant effect of the renin angiotensin system in the pathogenesis of renal inflammation.
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Colecciones
Articulos(ININCA)
Articulos de INST.DE INVEST.CARDIOLOGICAS (I)
Articulos de INST.DE INVEST.CARDIOLOGICAS (I)
Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Rukavina Mikusic, Natalia Lucía; Kravetz, Maria Cecilia; Kouyoumdzian, Nicolás Martín; Della Penna, S. L.; Roson, Maria Ines; et al.; Signaling pathways involved in renal oxidative injury: role of the vasoactive peptides and the renal dopaminergic system; Hindawi Publishing Corporation; Journal of Signal Transduction; 2014; 11-2014; 1-15; 731350
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