Mostrar el registro sencillo del ítem
dc.contributor.author
Caimi, Ayelen Tatiana
dc.contributor.author
Altube, María Julia
dc.contributor.author
de Farias, Marcelo Alexandre
dc.contributor.author
Portugal, Rodrigo Villares
dc.contributor.author
Perez, Ana Paula
dc.contributor.author
Romero, Eder Lilia
dc.contributor.author
Morilla, María José
dc.date.available
2020-02-20T19:59:07Z
dc.date.issued
2019-02
dc.identifier.citation
Caimi, Ayelen Tatiana; Altube, María Julia; de Farias, Marcelo Alexandre; Portugal, Rodrigo Villares; Perez, Ana Paula; et al.; Novel imiquimod nanovesicles for topical vaccination; Elsevier Science; Colloids and Surfaces B: Biointerfaces; 174; 2-2019; 536-543
dc.identifier.issn
0927-7765
dc.identifier.uri
http://hdl.handle.net/11336/98174
dc.description.abstract
Development of needle and pain free noninvasive immunization procedures is a top priority for public health agencies. In this work the topical adjuvant activity of the immunomodulator imiquimod (IMQ) carried by ultradeformable archaeosomes (UDA 2 ) (nanovesicles containing sn-2,3 ether linked phytanyl saturated archaeolipids) was surveyed and compared with that of ultradeformable liposomes lacking archaeolipids (UDL 2 ) and free IMQ, using the model antigen ovalbumin and a seasonal influenza vaccine in Balb/c mice. UDA 2 (250 ± 94 nm, -26 ± 4 mV Z potential) induced higher IMQ accumulation in human skin and higher production of TNF-α and IL-6 by macrophages and keratinocytes than free IMQ and UDL 2 . Mixed with ovalbumin, UDA 2 was more efficient at generating cellular response, as measured by an increase in serum IgG2a and INF-γ production by splenocytes, compared with free IMQ and UDL 2 . Moreover, mixed with a seasonal influenza vaccine UDA 2 produced same IgG titers and IgG2a/IgG1 isotypes ratio (≈1) than the subcutaneously administered influenza vaccine. Topical UDA 2 however, induced highest stimulation index and INF-γ levels by splenocytes. UDA 2 might be a promising adjuvant for topical immunization, since it produced cell-biased systemic response with ≈ 13-fold lower IMQ dose than the delivered as the commercial IMQ cream, Aldara.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ARCHAEOLIPIDS
dc.subject
CELLULAR RESPONSE
dc.subject
IMMUNOMODULATOR
dc.subject
INFLUENZA VACCINE
dc.subject.classification
Otras Nanotecnología
dc.subject.classification
Nanotecnología
dc.subject.classification
INGENIERÍAS Y TECNOLOGÍAS
dc.title
Novel imiquimod nanovesicles for topical vaccination
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-02-18T16:03:50Z
dc.journal.volume
174
dc.journal.pagination
536-543
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Caimi, Ayelen Tatiana. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Altube, María Julia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina
dc.description.fil
Fil: de Farias, Marcelo Alexandre. Centro Nacional de Pesquisa Em Energia E Materiais; Brasil
dc.description.fil
Fil: Portugal, Rodrigo Villares. Centro Nacional de Pesquisa Em Energia E Materiais; Brasil
dc.description.fil
Fil: Perez, Ana Paula. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina
dc.description.fil
Fil: Romero, Eder Lilia. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Morilla, María José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina
dc.journal.title
Colloids and Surfaces B: Biointerfaces
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0927776518308130
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.colsurfb.2018.11.031
Archivos asociados