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dc.contributor.author
Chemes, Hector Edgardo
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dc.contributor.author
Rawe, Vanesa Yanina
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dc.date.available
2020-02-18T18:28:59Z
dc.date.issued
2010-09
dc.identifier.citation
Chemes, Hector Edgardo; Rawe, Vanesa Yanina; The making of abnormal spermatozoa: Cellular and molecular mechanisms underlying pathological spermiogenesis; Springer; Cell and Tissue Research; 341; 3; 9-2010; 349-357
dc.identifier.issn
0302-766X
dc.identifier.uri
http://hdl.handle.net/11336/97931
dc.description.abstract
Fertilization in mammals occurs via a series of well-defined events in the secluded environment of the female reproductive tract. The mode of selection of the fertilizing spermatozoon nevertheless remains unknown. As has become evident during in vitro fertilization by sperm microinjection into the oocyte, abnormal spermatozoa can successfully fertilize oocytes. Under these extreme conditions, post-fertilization events, early embryonic development and implantation are significantly compromised indicating that the contribution of spermatozoa extends beyond sperm penetration. Microscopic identification of normal spermatozoa is a well-standardized procedure but insights into the mechanisms that lead to aberrant sperm differentiation and into the subcellular nature of sperm abnormalities have only recently begun to be obtained. The spermatozoon is the result of a complex development in which spermatid organelles give rise to various structural components with characteristic functions. Similar to other differentiated cells, the spermatozoon has a specific pathology that is most clearly identified by ultrastructural evaluation coupled with immunocytochemistry and molecular techniques. This multidisciplinary approach allows the precise characterization of sperm abnormalities, including structural, molecular and functional aspects. We summarize here studies of the physiopathology of spermiogenesis in two abnormal sperm phenotypes of infertile men: dysplasia of the fibrous sheath and acephalic spermatozoa/abnormal head-tail attachment. The characterization of the abnormalities of the tail cytoskeleton and centrioles has uncovered aspects of the subcellular basis of pathological spermiogenesis, has suggested experimental approaches to explore the nature of these anomalies and has opened the way for genetic studies that will ultimately lead to the design of the therapeutic tools of the future.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ABNORMAL SPERMIOGENESIS
dc.subject
ACEPHALIC SPERM
dc.subject
DYSPLASIA OF THE FIBROUS SHEATH
dc.subject
HUMAN
dc.subject
SPERM PATHOLOGY
dc.subject
SPERM PROTEASOMES
dc.subject.classification
Patología
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
The making of abnormal spermatozoa: Cellular and molecular mechanisms underlying pathological spermiogenesis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-02-07T13:47:34Z
dc.journal.volume
341
dc.journal.number
3
dc.journal.pagination
349-357
dc.journal.pais
Alemania
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dc.journal.ciudad
Berlín
dc.description.fil
Fil: Chemes, Hector Edgardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina
dc.description.fil
Fil: Rawe, Vanesa Yanina. Centro Médico de Fertilidad y Reproducción Asistida; España. Centro de Estudios en Ginecología y Reproducción; Argentina
dc.journal.title
Cell and Tissue Research
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s00441-010-1007-3
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s00441-010-1007-3
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