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dc.contributor.author
Ferraris, Jorge R.
dc.contributor.author
Pasqualini, Titania
dc.contributor.author
Alonso, Guillermo
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Legal, Susana
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Sorroche, Patricia Beatriz
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Galich, Ana María
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Coccia, Paula
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Ghezzi, Lidia
dc.contributor.author
Ferraris, Veronica
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Karabatas, Liliana Margarita
dc.contributor.author
Guida, María Clara
dc.contributor.author
Jasper, Hector Guillermo
dc.date.available
2020-02-18T15:31:52Z
dc.date.issued
2010-04
dc.identifier.citation
Ferraris, Jorge R.; Pasqualini, Titania; Alonso, Guillermo; Legal, Susana; Sorroche, Patricia Beatriz; et al.; A study on strategies for improving growth and body composition after renal transplantation; Springer; Pediatric Nephrology; 25; 4; 4-2010; 753-762
dc.identifier.issn
0931-041X
dc.identifier.uri
http://hdl.handle.net/11336/97885
dc.description.abstract
Allograft function and metabolic effects of four treatment regimens, namely, methylprednisone (MP) standard dose (MP-STD), deflazacort (DFZ), MP-late steroid withdrawal (MP-LSW), and MP-very low dose (MP-VLD), were evaluated in prepubertal patients. MP was decreased by month 4 post-transplantation to 0.2 mg/kg/day in MP-STD and DFZ patients and to <0.1 mg/kg/day in MP-LSW and MP-VLD patients. Starting in month 16 post-transplant, MP was switched to DFZ in the DFZ group and totally withdrawn in the MP-LSW group. Creatinine clearance diminished in the MP-STD and MP-LSW groups from 77 ± 6 to 63 ± 6 ml/min/1.73 m2and from 103 ± 5 to 78 ± 3 ml/min/1.73 m2, respectively (p < 0.01 and p < 0.001, respectively). Height increased >0.5 SDS only in the MP-LSW and MP-VLD groups. The body mass index and fat body mass for height-age increased only in the MP-STD patients (p < 0.05 and p < 0.01, respectively). Fat body mass decreased in the DFZ group (p < 0.05), total cholesterol and LDL-cholesterol increased in the MP-STD group, while LDL-cholesterol and total cholesterol/HDL-cholesterol ratio decreased in the DFZ group (p < 0.01). Lumbar spine bone mineral density (BMD) for height-age showed an increase in the MP-LSW and MP-VLD groups (p < 0.01). Our data suggest that MP-LSW and MP-VLD strategies improve linear growth, BMD, the peripheral distribution of fat, and preservation of the bone-muscle unit and maintain the normal lipid profile. The MP-LSW patients had a concerning rate of acute rejections and graft function deterioration in prepubertal patients.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
BODY GROWTH
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BONE MINERAL DENSITY
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CYCLOSPORIN
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DEFLAZACORT
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DYSLIPOPROTEINEMIA
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METHYLPREDNISONE
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RENAL TRANSPLANTATION
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TACROLIMUS
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Otras Ciencias de la Salud
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Ciencias de la Salud
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
A study on strategies for improving growth and body composition after renal transplantation
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-02-07T13:44:59Z
dc.journal.volume
25
dc.journal.number
4
dc.journal.pagination
753-762
dc.journal.pais
Alemania
dc.journal.ciudad
Berlin
dc.description.fil
Fil: Ferraris, Jorge R.. Hospital Italiano; Argentina. Universidad de Buenos Aires; Argentina
dc.description.fil
Fil: Pasqualini, Titania. Hospital Italiano; Argentina
dc.description.fil
Fil: Alonso, Guillermo. Hospital Italiano; Argentina
dc.description.fil
Fil: Legal, Susana. Hospital Italiano; Argentina
dc.description.fil
Fil: Sorroche, Patricia Beatriz. Hospital Italiano; Argentina
dc.description.fil
Fil: Galich, Ana María. Hospital Italiano; Argentina
dc.description.fil
Fil: Coccia, Paula. Hospital Italiano; Argentina
dc.description.fil
Fil: Ghezzi, Lidia. Hospital Italiano; Argentina
dc.description.fil
Fil: Ferraris, Veronica. Hospital Italiano; Argentina
dc.description.fil
Fil: Karabatas, Liliana Margarita. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina
dc.description.fil
Fil: Guida, María Clara. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina
dc.description.fil
Fil: Jasper, Hector Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina
dc.journal.title
Pediatric Nephrology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00467-010-1458-5
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s00467-010-1458-5
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