Mostrar el registro sencillo del ítem
dc.contributor.author
John, Minnie
dc.contributor.author
Keller, Marla J.
dc.contributor.author
Fam, Ehsan H.
dc.contributor.author
Cheshenko, Natalia
dc.contributor.author
Hogarty, Kathleen
dc.contributor.author
Kosowitz, Andrea
dc.contributor.author
Wallenstein, Sylvan
dc.contributor.author
Carlucci, Maria Josefina
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.contributor.author
Tuyama, Ana C.
dc.contributor.author
Lu, Wuyyan
dc.contributor.author
Klotman, Mary E.
dc.contributor.author
Lehrer, Robert I.
dc.contributor.author
Herold, Betsy C.
dc.date.available
2020-02-17T19:04:39Z
dc.date.issued
2005-11
dc.identifier.citation
John, Minnie; Keller, Marla J.; Fam, Ehsan H.; Cheshenko, Natalia; Hogarty, Kathleen; et al.; Cervicovaginal secretions contribute to innate resistance to herpes simplex virus infection; Oxford University Press; Journal Of Infectious Diseases; 192; 10; 11-2005; 1731-1740
dc.identifier.issn
0022-1899
dc.identifier.uri
http://hdl.handle.net/11336/97785
dc.description.abstract
Defining and preserving the innate antiviral activity found in cervicovaginal secretions is critical. Cervicovaginal lavage (CVL) samples were obtained from 20 healthy women and evaluated for anti-herpes simplex virus (HSV) activity. CVL samples reduced HSV-2 yields by 23-fold (median), and the anti-HSV activity of CVL samples correlated with the concentration of human neutrophil peptides (HNP)-1-3. Both CVL samples and HNP-1-3 interacted with virus and prevented entry after binding. Substantially less protective activity was observed in CVL samples obtained from 20 human immunodeficiency virus-infected subjects, but the addition of CVL samples from healthy subjects enhanced the antiviral activity. The significance of the innate activity was further demonstrated by showing that CVL samples prevented murine genital herpes. Fourteen of 15 mice were protected from genital herpes if they were challenged with HSV-2 pretreated with CVL samples from healthy subjects. In contrast, all 15 mice challenged with untreated HSV-2 died. These findings are evidence that cervicovaginal secretions contribute to innate resistance to HSV-2 and identify defensins as contributors to this activity.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Oxford University Press
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
HERPES SIMPLEX VIRUS
dc.subject
CERVICOVAGINAL SECRETIONS
dc.subject.classification
Biología Celular, Microbiología
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
Ciencias Biológicas
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.title
Cervicovaginal secretions contribute to innate resistance to herpes simplex virus infection
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-02-13T20:11:28Z
dc.journal.volume
192
dc.journal.number
10
dc.journal.pagination
1731-1740
dc.journal.pais
Reino Unido
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.journal.ciudad
Oxford
dc.description.fil
Fil: John, Minnie. Mount Sinai School of Medicine; Estados Unidos
dc.description.fil
Fil: Keller, Marla J.. Mount Sinai School of Medicine; Estados Unidos
dc.description.fil
Fil: Fam, Ehsan H.. Mount Sinai School of Medicine; Estados Unidos
dc.description.fil
Fil: Cheshenko, Natalia. Mount Sinai School of Medicine; Estados Unidos
dc.description.fil
Fil: Hogarty, Kathleen. Mount Sinai School of Medicine; Estados Unidos
dc.description.fil
Fil: Kosowitz, Andrea. Mount Sinai School of Medicine; Estados Unidos
dc.description.fil
Fil: Wallenstein, Sylvan. Mount Sinai School of Medicine; Estados Unidos
dc.description.fil
Fil: Carlucci, Maria Josefina. Mount Sinai School of Medicine; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Tuyama, Ana C.. Mount Sinai School of Medicine; Estados Unidos
dc.description.fil
Fil: Lu, Wuyyan. University of Maryland; Estados Unidos
dc.description.fil
Fil: Klotman, Mary E.. Mount Sinai School of Medicine; Estados Unidos
dc.description.fil
Fil: Lehrer, Robert I.. University of California at Los Angeles; Estados Unidos
dc.description.fil
Fil: Herold, Betsy C.. Mount Sinai School of Medicine; Estados Unidos
dc.journal.title
Journal Of Infectious Diseases
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/jid/article/192/10/1731/876451
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1086/497168
Archivos asociados