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dc.contributor.author
Tuyama, Ana C. G.
dc.contributor.author
Cheshenko, Natalia
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Carlucci, Maria Josefina
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dc.contributor.author
Li, Jin Hua
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Goldberg, Cindy L.
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Waller, Donald P.
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Anderson, Robert A.
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Profy, Albert T.
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Klotman, Mary E.
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Keller, Maria J.
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Herold, Betsy C.
dc.date.available
2020-02-17T19:04:31Z
dc.date.issued
2006-09
dc.identifier.citation
Tuyama, Ana C. G.; Cheshenko, Natalia; Carlucci, Maria Josefina; Li, Jin Hua; Goldberg, Cindy L.; et al.; ACIDFORM inactivates herpes simplex virus and prevents genital herpes in a mouse model: Optimal candidate for microbicide combinations; Oxford University Press; Journal Of Infectious Diseases; 194; 6; 9-2006; 795-803
dc.identifier.issn
0022-1899
dc.identifier.uri
http://hdl.handle.net/11336/97784
dc.description.abstract
The acidic vaginal milieu is presumed to inactivate pathogens but is neutralized by semen. This notion fostered the development of acid-buffering products, such as ACIDFORM (developed by Program for Topical Prevention of Conception and Disease, Rush University, and licensed by Instead), as microbicides. However, the extent and mechanism of protective activity provided by buffering gels is not known. Exposure of herpes simplex virus (HSV) to pH 4.5 or lower irreversibly inactivated HSV and reduced HSV yields by at least 90%; exposure to pH 5.0 had little or no effect. Pretreatment of HSV-2 with pH 3.5-4.5 triggered proteolysis, disrupting the HSV particle and resulting in a reduction in binding and invasion. ACIDFORM protected 21 (81%) of 26 mice from genital herpes, compared with 3 (12%) of 25 mice who received a placebo gel. ACIDFORM retained significant activity if mice were challenged with HSV delivered in seminal fluid. These findings suggest that ACIDFORM offers considerable protection against HSV and may be an optimal candidate for developing combination microbicides.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Oxford University Press
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
MICROBICIDES
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ANTIVIRAL
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HERPES
dc.subject.classification
Biología Celular, Microbiología
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
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dc.title
ACIDFORM inactivates herpes simplex virus and prevents genital herpes in a mouse model: Optimal candidate for microbicide combinations
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-02-13T20:09:50Z
dc.journal.volume
194
dc.journal.number
6
dc.journal.pagination
795-803
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Oxford
dc.description.fil
Fil: Tuyama, Ana C. G.. Mount Sinai School of Medicine; Estados Unidos
dc.description.fil
Fil: Cheshenko, Natalia. Mount Sinai School of Medicine; Estados Unidos
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Fil: Carlucci, Maria Josefina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Mount Sinai School of Medicine; Estados Unidos
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Fil: Li, Jin Hua. Mount Sinai School of Medicine; Estados Unidos
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Fil: Goldberg, Cindy L.. Mount Sinai School of Medicine; Estados Unidos
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Fil: Waller, Donald P.. University of Illinois; Estados Unidos
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Fil: Anderson, Robert A.. Rush University; Argentina
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Fil: Profy, Albert T.. Indevus Pharmaceuticals; Estados Unidos
dc.description.fil
Fil: Klotman, Mary E.. Mount Sinai School of Medicine; Estados Unidos
dc.description.fil
Fil: Keller, Maria J.. Mount Sinai School of Medicine; Estados Unidos
dc.description.fil
Fil: Herold, Betsy C.. Mount Sinai School of Medicine; Estados Unidos
dc.journal.title
Journal Of Infectious Diseases
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1086/506948
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/jid/article/194/6/795/865061
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