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dc.contributor.author
Baravalle, Celina
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dc.contributor.author
Dallard, Bibiana Elisabet
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dc.contributor.author
Ortega, Hugo Hector
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dc.contributor.author
Neder, V.E.
dc.contributor.author
Canavesio, V.R.
dc.contributor.author
Calvinho, Luis Fernando
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dc.date.available
2020-02-14T20:21:08Z
dc.date.issued
2010-12
dc.identifier.citation
Baravalle, Celina; Dallard, Bibiana Elisabet; Ortega, Hugo Hector; Neder, V.E.; Canavesio, V.R.; et al.; Effect of Panax ginseng on cytokine expression in bovine mammary glands at drying off; Elsevier Science; Veterinary Immunology And Immunopathology; 138; 3; 12-2010; 224-230
dc.identifier.issn
0165-2427
dc.identifier.uri
http://hdl.handle.net/11336/97635
dc.description.abstract
Biological response modifiers (BRM) are agents that modify the host's response to pathogens with resultant beneficial prophylactic or therapeutic effects. The objectives of this study were to describe the immunomodulatory effects of Panax ginseng (GS) on bovine mammary glands at the end of lactation. Eight mammary quarters from six nonpregnant cows in late lactation were infused with 10 mL of BRM (3 mg/mL), six quarters were treated with placebo (vehicle alone) and six quarters were maintained as uninoculated controls. Milk samples were collected at different time points for detection of specific cytokines mRNA by RT-PCR and Western blotting assay. A significant increase of IL-1α, IL-1β and TNF-α mRNA expression was observed in BRM-treated compared with placebo-treated quarters at 48 h post-treatment (pt) (P<0.05). A 17 kDa TNF-α band expressed a sharp elevation at 24 h and reduction in its level at 48 h pt in BRM-treated quarters. Differences in this cytokine level between 24 and 48 h pt times were significant (P<0.05). GS extract inoculation at drying off was associated with somatic cell counts increase, cytokines mRNA transcription and the presence of TNF-α in milk and can therefore exert immunomodulating effects in bovine mammary gland at drying off.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
BOVINE MAMMARY GLAND
dc.subject
CYTOKINES
dc.subject
INVOLUTION
dc.subject
PANAX GINSENG
dc.subject.classification
Ciencias Veterinarias
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dc.subject.classification
Ciencias Veterinarias
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dc.subject.classification
CIENCIAS AGRÍCOLAS
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dc.title
Effect of Panax ginseng on cytokine expression in bovine mammary glands at drying off
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-02-13T19:00:25Z
dc.journal.volume
138
dc.journal.number
3
dc.journal.pagination
224-230
dc.journal.pais
Países Bajos
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dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Baravalle, Celina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Litoral; Argentina
dc.description.fil
Fil: Dallard, Bibiana Elisabet. Universidad Nacional del Litoral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Ortega, Hugo Hector. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Litoral; Argentina
dc.description.fil
Fil: Neder, V.E.. Instituto Nacional de Tecnología Agropecuaria Eea, Rafaela; Argentina
dc.description.fil
Fil: Canavesio, V.R.. Instituto Nacional de Tecnología Agropecuaria Eea, Rafaela; Argentina
dc.description.fil
Fil: Calvinho, Luis Fernando. Instituto Nacional de Tecnología Agropecuaria Eea, Rafaela; Argentina. Universidad Nacional del Litoral; Argentina
dc.journal.title
Veterinary Immunology And Immunopathology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://sciencedirect.com/science/journal/01652427
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.vetimm.2010.07.019
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