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dc.contributor.author
Molejon, Maria Ines
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dc.contributor.author
Swayden, Mirna
dc.contributor.author
Fanale, Daniele
dc.contributor.author
Bintz, Jennifer
dc.contributor.author
Gayet, Odile
dc.contributor.author
Soubeyran, Philippe
dc.contributor.author
Iovanna, Juan Lucio
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dc.date.available
2020-02-14T20:18:35Z
dc.date.issued
2018-07
dc.identifier.citation
Molejon, Maria Ines; Swayden, Mirna; Fanale, Daniele; Bintz, Jennifer; Gayet, Odile; et al.; Chloroquine plays a cell-dependent role in the response to treatment of pancreatic adenocarcinoma; Impact Journals; Oncotarget; 9; 56; 7-2018; 30837-30846
dc.identifier.issn
1949-2553
dc.identifier.uri
http://hdl.handle.net/11336/97633
dc.description.abstract
In this study, our aim is to assess the role played by autophagy and its inhibition in the different PDAC cellular compartments, and its involvement in chemo-resistance using primary human pancreatic cancer-derived cells (PCC) and Cancer Associated Fibroblasts (CAF). Autophagy flux, as measured by LC3-I and -II in the presence of Chloroquine, showed a variable level in PCC and CAFs. We found no correlation between autophagy level and degree of tumor differentiation. Association of Chloroquine with gemcitabine, 5FU, oxaliplatin, irinotecan and docetaxel revealed that its effect on survival is cell- and drug-dependent in vitro and in vivo. In addition, we demonstrated that autophagy in CAFs can play an important role in sensitizing PDAC to anticancer treatments since its inhibition increased the resistance of PCCs to gemcitabine. In conclusion, this work clearly shows a heterogeneity in the effect of Chloroquine and highlights a role of CAFs autophagy in sensitizing tumors to treatments. It also reveals that the role of autophagy is more complex than expected in PDAC as well as its sensitivity to treatments.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Impact Journals
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
AUTOPHAGY
dc.subject
CHLOROQUINE
dc.subject
GEMCITABINE
dc.subject
PANCREAS CANCER
dc.subject.classification
Otras Ciencias de la Salud
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dc.subject.classification
Ciencias de la Salud
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Chloroquine plays a cell-dependent role in the response to treatment of pancreatic adenocarcinoma
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-22T17:32:56Z
dc.journal.volume
9
dc.journal.number
56
dc.journal.pagination
30837-30846
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Molejon, Maria Ines. Institut National de la Santé et de la Recherche Médicale; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Ciencias de la Tierra y Ambientales de La Pampa. Universidad Nacional de La Pampa. Facultad de Ciencias Exactas y Naturales. Instituto de Ciencias de la Tierra y Ambientales de La Pampa; Argentina
dc.description.fil
Fil: Swayden, Mirna. Institut National de la Santé et de la Recherche Médicale; Francia
dc.description.fil
Fil: Fanale, Daniele. 3 Department of Surgical, Oncological and Oral Sciences, Section of Medical Oncology, University of Palermo, 90127 Palermo, Italy.; Argentina. University of Palermo. Department of Surgical, Oncological and Oral Sciences; Italia
dc.description.fil
Fil: Bintz, Jennifer. Institut National de la Santé et de la Recherche Médicale; Francia
dc.description.fil
Fil: Gayet, Odile. Institut National de la Santé et de la Recherche Médicale; Francia
dc.description.fil
Fil: Soubeyran, Philippe. Institut National de la Santé et de la Recherche Médicale; Francia
dc.description.fil
Fil: Iovanna, Juan Lucio. Institut National de la Santé et de la Recherche Médicale; Francia
dc.journal.title
Oncotarget
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.18632/oncotarget.25745
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=25745&path[]=80543
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