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dc.contributor.author
Beldomenico, Pablo Martín
dc.contributor.author
Telfer, Sandra
dc.contributor.author
Gebert, Stephanie
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Lukomski, Lukasz
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Bennett, Malcolm
dc.contributor.author
Begon, Michael
dc.date.available
2020-02-14T20:04:17Z
dc.date.issued
2009-09
dc.identifier.citation
Beldomenico, Pablo Martín; Telfer, Sandra; Gebert, Stephanie; Lukomski, Lukasz; Bennett, Malcolm; et al.; The vicious circle and infection intensity: The case of Trypanosoma microti in field vole populations; Elsevier; Epidemics; 1; 3; 9-2009; 162-167
dc.identifier.issn
1755-4365
dc.identifier.uri
http://hdl.handle.net/11336/97619
dc.description.abstract
Objective: In natural populations, infection and condition may act synergistically to trigger a vicious circle: poor condition predisposes to host infections, which further reduce condition, and so on. If this vicious circle originates from a reduced resistance to infection, it will not only result in greater proneness to becoming infected of those that are in poorer condition, but it may also cause infections of higher intensity. Here, we investigate the temporal relationship between host condition and intensity of infection by a specific pathogen using as a system the dynamics of the protozoan Trypanosoma microti in field vole (Microtus agrestis) populations. Methods and results: With two years of longitudinal data from three monthly-sampled populations, we evaluated if individuals acquiring a high intensity of infection previously had lower haematological indicators of condition (red blood cells [RBCs] and lymphocyte counts) than those that acquired lower infection intensities. Also, the association of these indicators with past and present trypanosome blood levels was investigated. The individuals that developed high levels of parasitaemia were those that previously had low lymphocyte counts. Greater intensity of infection corresponded with lower RBCs only in low to moderate weight females, and no effect of intensity of infection on lymphocyte counts was observed. However, delayed effects of high trypanosome intensity were seen on both RBCs and lymphocytes. Conclusions: The vicious circle may also result in high infection intensity: individuals in poor condition are not only more likely to become infected by one pathogen; they may also be the most important source of infection for that and for other pathogens, and thus key protagonists for parasite dynamics.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
DISEASE ECOLOGY
dc.subject
VICIOUS CIRCLE
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TRYPANOSOMA
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Ciencias Veterinarias
dc.subject.classification
Ciencias Veterinarias
dc.subject.classification
CIENCIAS AGRÍCOLAS
dc.title
The vicious circle and infection intensity: The case of Trypanosoma microti in field vole populations
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-02-13T18:54:03Z
dc.journal.volume
1
dc.journal.number
3
dc.journal.pagination
162-167
dc.journal.pais
Países Bajos
dc.description.fil
Fil: Beldomenico, Pablo Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina
dc.description.fil
Fil: Telfer, Sandra. University of Liverpool; Reino Unido
dc.description.fil
Fil: Gebert, Stephanie. University of Liverpool; Reino Unido
dc.description.fil
Fil: Lukomski, Lukasz. University of Liverpool; Reino Unido
dc.description.fil
Fil: Bennett, Malcolm. University of Liverpool; Reino Unido
dc.description.fil
Fil: Begon, Michael. University of Liverpool; Reino Unido
dc.journal.title
Epidemics
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.epidem.2009.05.002
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