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dc.contributor.author
Militello, Rodrigo Damián
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dc.contributor.author
Colombo, Maria Isabel
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dc.date.available
2016-12-19T18:17:48Z
dc.date.issued
2013-09
dc.identifier.citation
Militello, Rodrigo Damián; Colombo, Maria Isabel; Small GTPases as regulators of cell division; Landes Bioscience; Communicative & Integrative Biology; 6; 5; 9-2013; 254601-254604
dc.identifier.issn
1942-0889
dc.identifier.uri
http://hdl.handle.net/11336/9735
dc.description.abstract
The superfamily of small GTPases serves as a signal transducer to regulate a diverse array of cellular functions. The members of this superfamily are structurally and functionally classified into at least 5 groups (Ras, Rho/Rac, Rab, Arf, and Ran) and they are involved in the control of cell proliferation and differentiation, regulation of the actin cytoskeleton, membrane trafficking, and nuclear transport. It is widely reported that members of the Rab family participate in the control of intracellular membrane trafficking through the interaction with specific effector molecules. However, many Rabs and other small GTPases have also been shown to function in cell division. In this review, we discuss current knowledge about Rab proteins regulating different stages of the cell cycle, such as the congregation and segregation of chromosomes (during metaphase) and the final stage of cell division known as cytokinesis, in which a cell is cleaved originating 2 daughter cells.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Landes Bioscience
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Rab Gtpases
dc.subject
Mitosis
dc.subject
Small Gtpases
dc.subject
Rabs
dc.subject
Cell Division
dc.subject
Cytokinesis
dc.subject
Chromosome Segregation
dc.subject.classification
Otras Ciencias de la Salud
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dc.subject.classification
Ciencias de la Salud
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Small GTPases as regulators of cell division
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-09-19T18:44:14Z
dc.journal.volume
6
dc.journal.number
5
dc.journal.pagination
254601-254604
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Austin Texas
dc.description.fil
Fil: Militello, Rodrigo Damián. Consejo Nacional de Investigaciones Cientiâficas y Tecnicas. Centro Cientifico Tecnologico Mendoza. Instituto Histologia y Embriologia de Mendoza "dr. M. Burgos"; Argentina
dc.description.fil
Fil: Colombo, Maria Isabel. Consejo Nacional de Investigaciones Cientiâficas y Tecnicas. Centro Cientifico Tecnologico Mendoza. Instituto Histologia y Embriologia de Mendoza "dr. M. Burgos"; Argentina
dc.journal.title
Communicative & Integrative Biology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/abs/10.4161/cib.25460
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.4161/cib.25460
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