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dc.contributor.author
Loureiro, Maria Eugenia
dc.contributor.author
Zorzetto Fernandes, Andre Luiz
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Radoshitzky, Sheli
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Chi, Xiaoli
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Dallari, Simone
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Marooki, Nuha
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Lèger, Psylvia
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Foscaldi, Sabrina Andrea
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Harjono, Vince
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Sharma, Sonia
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Zid, Brian M.
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Lopez, Nora Mabel
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de la Torre, Juan Carlos
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Bavari, Sina
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Zuniga, Elina Isabel
dc.date.available
2020-02-12T17:58:09Z
dc.date.issued
2018-07
dc.identifier.citation
Loureiro, Maria Eugenia; Zorzetto Fernandes, Andre Luiz; Radoshitzky, Sheli; Chi, Xiaoli; Dallari, Simone; et al.; DDX3 suppresses type I interferons and favors viral replication during Arenavirus infection; Public Library of Science; Plos Pathogens; 14; 7; 7-2018; 1-28; e1007125
dc.identifier.issn
1553-7366
dc.identifier.uri
http://hdl.handle.net/11336/97302
dc.description.abstract
Several arenaviruses cause hemorrhagic fever (HF) diseases that are associated with high morbidity and mortality in humans. Accordingly, HF arenaviruses have been listed as top-priority emerging diseases for which countermeasures are urgently needed. Because arenavirus nucleoprotein (NP) plays critical roles in both virus multiplication and immune-evasion, we used an unbiased proteomic approach to identify NP-interacting proteins in human cells. DDX3, a DEAD-box ATP-dependent-RNA-helicase, interacted with NP in both NP-transfected and virus-infected cells. Importantly, DDX3 deficiency compromised the propagation of both Old and New World arenaviruses, including the HF arenaviruses Lassa and Junin viruses. The DDX3 role in promoting arenavirus multiplication associated with both a previously un-recognized DDX3 inhibitory role in type I interferon production in arenavirus infected cells and a positive DDX3 effect on arenavirus RNA synthesis that was dependent on its ATPase and Helicase activities. Our results uncover novel mechanisms used by arenaviruses to exploit the host machinery and subvert immunity, singling out DDX3 as a potential host target for developing new therapies against highly pathogenic arenaviruses.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Public Library of Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ARENAVIRUS
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DDX3
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REPLICATION
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INTERFERON
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Virología
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
DDX3 suppresses type I interferons and favors viral replication during Arenavirus infection
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-01-30T22:00:42Z
dc.journal.volume
14
dc.journal.number
7
dc.journal.pagination
1-28; e1007125
dc.journal.pais
Estados Unidos
dc.journal.ciudad
San Francisco
dc.description.fil
Fil: Loureiro, Maria Eugenia. University of California at San Diego; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Zorzetto Fernandes, Andre Luiz. University of California at San Diego; Estados Unidos
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Fil: Radoshitzky, Sheli. United States Army Medical Research Institute of Infectious Diseases; Estados Unidos
dc.description.fil
Fil: Chi, Xiaoli. United States Army Medical Research Institute of Infectious Diseases; Estados Unidos
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Fil: Dallari, Simone. University of California at San Diego; Estados Unidos
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Fil: Marooki, Nuha. University of California at San Diego; Estados Unidos
dc.description.fil
Fil: Lèger, Psylvia. University of California at San Diego; Estados Unidos
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Fil: Foscaldi, Sabrina Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencia y Tecnología "Dr. César Milstein". Fundación Pablo Cassará. Instituto de Ciencia y Tecnología "Dr. César Milstein"; Argentina
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Fil: Harjono, Vince. University of California at San Diego; Estados Unidos
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Fil: Sharma, Sonia. La Jolla Institute for Allergy and Immunology; Estados Unidos
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Fil: Zid, Brian M.. University of California at San Diego; Estados Unidos
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Fil: Lopez, Nora Mabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencia y Tecnología "Dr. César Milstein". Fundación Pablo Cassará. Instituto de Ciencia y Tecnología "Dr. César Milstein"; Argentina. Ministerio de Producción y Trabajo. Secretaría de Gobierno de Agroindustria. Servicio Nacional de Sanidad y Calidad Agroalimentaria. Centro de Virología Humana y Animal. - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Virología Humana y Animal; Argentina
dc.description.fil
Fil: de la Torre, Juan Carlos. The Scripps Research Institute; Estados Unidos
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Fil: Bavari, Sina. United States Army Medical Research Institute of Infectious Diseases; Estados Unidos
dc.description.fil
Fil: Zuniga, Elina Isabel. University of California at San Diego; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Plos Pathogens
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1007125
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1371/journal.ppat.1007125
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