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dc.contributor.author
de Athayde Moncorvo Collado, Alejandro
dc.contributor.author
Salazar, Paula Belén
dc.contributor.author
Minahk, Carlos Javier
dc.date.available
2020-02-11T20:05:47Z
dc.date.issued
2018-08
dc.identifier.citation
de Athayde Moncorvo Collado, Alejandro; Salazar, Paula Belén; Minahk, Carlos Javier; Enterodiol is actively transported by rat Liver cell membranes; Springer; Journal of Membrane Biology; 251; 4; 8-2018; 593-600
dc.identifier.issn
0022-2631
dc.identifier.uri
http://hdl.handle.net/11336/97212
dc.description.abstract
The interaction of enterodiol and the well-described polyphenol epigallocatechin gallate (EGCG) with hepatic membranes has been matter of interest in the last few years. On one hand, EGCG is only able to bind to the phospholipid polar head groups, as it has been already described in synthetic lipid bilayers and erythrocyte membranes but cannot get inserted into the hydrophobic core or be transported into the lumen of membrane vesicles. On the other, enterodiol has no interaction with non-energized membranes either, but it is able to interact and even be transported upon addition of ATP. In fact, the ATPase activity undergoes a twofold increase in the presence of enterodiol but not in the presence of EGCG. This is the first report on the transport of enterodiol by liver membranes, and it may help explain the rather high blood concentrations of this estrogenic enterolignan compared to EGCG, which is extensively metabolized by the intestine and the liver. The present results suggest that a fraction of enterodiol may escape the liver inactivation by being pumped out from the hepatocytes to the bloodstream.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ATPASE ACTIVITY
dc.subject
LIGNANS
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MEMBRANE BINDING
dc.subject
POLYPHENOLS
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Biofísica
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Enterodiol is actively transported by rat Liver cell membranes
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-16T19:27:48Z
dc.identifier.eissn
1432-1424
dc.journal.volume
251
dc.journal.number
4
dc.journal.pagination
593-600
dc.journal.pais
Alemania
dc.journal.ciudad
Berlín
dc.description.fil
Fil: de Athayde Moncorvo Collado, Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
dc.description.fil
Fil: Salazar, Paula Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
dc.description.fil
Fil: Minahk, Carlos Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
dc.journal.title
Journal of Membrane Biology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://link.springer.com/10.1007/s00232-018-0035-x
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s00232-018-0035-x
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