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dc.contributor.author
Fernandez, Ariel
dc.contributor.author
Berry, R. Stephen
dc.date.available
2020-02-10T15:58:57Z
dc.date.issued
2004-09-14
dc.identifier.citation
Fernandez, Ariel; Berry, R. Stephen; Molecular dimension explored in evolution to promote proteomic complexity; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 101; 37; 14-9-2004; 13460-13465
dc.identifier.issn
0027-8424
dc.identifier.uri
http://hdl.handle.net/11336/97065
dc.description.abstract
The architecture of present-day protein interaction networks depends on how protein associations evolved. Here, we explore how and why evolution-related mutations influence protein structure to promote protein associations, and thereby network development. We specifically address two questions: (i) How can protein folds remain conserved while proteins accommodate new binding partnerships as genes duplicate? (ii) What is the structural/molecular basis for hub proteins being the most likely to acquire new connections? The answers stem from the examination of the structure wrapping, or protection from water attack. Wrapping is shown to be a crucial consideration in the exploration and evolution of proteomic interactivity.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
National Academy of Sciences
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
COMPLEXITY
dc.subject
EVOLUTION
dc.subject
PROTEIN INTERACTION
dc.subject.classification
Física Atómica, Molecular y Química
dc.subject.classification
Ciencias Físicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Molecular dimension explored in evolution to promote proteomic complexity
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-12-18T13:57:44Z
dc.journal.volume
101
dc.journal.number
37
dc.journal.pagination
13460-13465
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Fernandez, Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina. University of Chicago; Estados Unidos
dc.description.fil
Fil: Berry, R. Stephen. University of Chicago; Estados Unidos
dc.journal.title
Proceedings of the National Academy of Sciences of The United States of America
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1073/pnas.0405585101
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.pnas.org/content/101/37/13460
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