Artículo
Human non-REM sleep and the mean global BOLD signal
Fecha de publicación:
11/2019
Editorial:
Nature Publishing Group
Revista:
Journal Of Cerebral Blood Flow And Metabolism
ISSN:
0271-678X
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
A hallmark of non-rapid eye movement (REM) sleep is the decreased brain activity as measured by global reductions in cerebral blood flow, oxygen metabolism, and glucose metabolism. It is unknown whether the blood oxygen level dependent (BOLD) signal undergoes similar changes. Here we show that, in contrast to the decreases in blood flow and metabolism, the mean global BOLD signal increases with sleep depth in a regionally non-uniform manner throughout gray matter. We relate our findings to the circulatory and metabolic processes influencing the BOLD signal and conclude that because oxygen consumption decreases proportionately more than blood flow in sleep, the resulting decrease in paramagnetic deoxyhemoglobin accounts for the increase in mean global BOLD signal.
Palabras clave:
BOHR EFFECT
,
FMRI BOLD
,
GLOBAL SIGNAL
,
OXYHEMOGLOBIN DISSOCIATION CURVE
,
SLEEP
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Colecciones
Articulos(IFIBA)
Articulos de INST.DE FISICA DE BUENOS AIRES
Articulos de INST.DE FISICA DE BUENOS AIRES
Citación
McAvoy, Mark P.; Tagliazucchi, Enzo Rodolfo; Laufs, Helmut; Raichle, Marcus E.; Human non-REM sleep and the mean global BOLD signal; Nature Publishing Group; Journal Of Cerebral Blood Flow And Metabolism; 39; 11; 11-2019; 2210-2222
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