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dc.contributor.author
Palomeque, Miriam Edid  
dc.contributor.author
Fernández Band, Beatriz Susana  
dc.date.available
2020-02-07T18:36:12Z  
dc.date.issued
2002-09  
dc.identifier.citation
Palomeque, Miriam Edid; Fernández Band, Beatriz Susana; Flow injection biamperometric determination of captopril; Elsevier Science; Journal of Pharmaceutical and Biomedical Analysis; 30; 3; 9-2002; 547-552  
dc.identifier.issn
0731-7085  
dc.identifier.uri
http://hdl.handle.net/11336/96897  
dc.description.abstract
An automated method to determine captopril (1-[(2S)-3-mercapto-2-methylpropionyl]-L-proline) is proposed. A flow injection manifold based on the indirect biamperometric detection of the captopril by using Fe(III)/Fe(II) as an indicating redox system and a Z-shaped flow-cell configuration, was developed. The calibration curve is linear over the range 0.03-3.6 μg ml-1 of captopril. The relative standard deviation for the determination of 0.76 μg ml-1 of captopril is 0.97% (n=12) and the sample throughput is 69 h-1. This method was applied to the determination of captopril to commercially available pharmaceutical preparations.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier Science  
dc.rights
info:eu-repo/semantics/restrictedAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
BIAMPEROMETRY  
dc.subject
CAPTOPRIL  
dc.subject
FLOW INJECTION  
dc.subject.classification
Química Analítica  
dc.subject.classification
Ciencias Químicas  
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS  
dc.title
Flow injection biamperometric determination of captopril  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2019-11-27T14:52:54Z  
dc.journal.volume
30  
dc.journal.number
3  
dc.journal.pagination
547-552  
dc.journal.pais
Países Bajos  
dc.journal.ciudad
Amsterdam  
dc.description.fil
Fil: Palomeque, Miriam Edid. Universidad Nacional del Sur. Departamento de Química. Química Analitica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina  
dc.description.fil
Fil: Fernández Band, Beatriz Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina. Universidad Nacional del Sur. Departamento de Química. Química Analitica; Argentina  
dc.journal.title
Journal of Pharmaceutical and Biomedical Analysis  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/S0731-7085(02)00315-1  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0731708502003151