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dc.contributor.author
Wang, Jing
dc.contributor.author
Bains, Henrietta
dc.contributor.author
Anastasia Gonzalez, Agustin
dc.contributor.author
Bracken, Clay
dc.date.available
2020-02-07T18:07:40Z
dc.date.issued
2018-04
dc.identifier.citation
Wang, Jing; Bains, Henrietta; Anastasia Gonzalez, Agustin; Bracken, Clay; NMR backbone resonance assignments of the prodomain variants of BDNF in the urea denatured state; Springer; Biomolecular Nmr Assignments; 12; 1; 4-2018; 43-45
dc.identifier.issn
1874-2718
dc.identifier.uri
http://hdl.handle.net/11336/96880
dc.description.abstract
Brain derived neurotrophic factor (BDNF) is a member of the neurotrophin family of proteins which plays a central role in neuronal survival, growth, plasticity and memory. A single Val66Met variant has been identified in the prodomain of human BDNF that is associated with anxiety, depression and memory disorders. The structural differences within the full-length prodomain Val66 and Met66 isoforms could shed light on the mechanism of action of the Met66 and its impact on the development of neuropsychiatric-associated disorders. In the present study, we report the backbone 1H, 13C, and 15N NMR assignments of both full-length Val66 and Met66 prodomains in the presence of 2 M urea. These conditions were utilized to suppress residual structure and aid subsequent native state structural investigations aimed at mapping and identifying variant-dependent conformational differences under native-state conditions.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
BDNF
dc.subject
INTRINSICALLY DISORDERED PROTEINS
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NEUROTROPHIN
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PRODOMAIN
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UREA
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VAL66MET
dc.subject.classification
Otras Ciencias Biológicas
dc.subject.classification
Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
NMR backbone resonance assignments of the prodomain variants of BDNF in the urea denatured state
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-23T14:26:01Z
dc.identifier.eissn
1874-270X
dc.journal.volume
12
dc.journal.number
1
dc.journal.pagination
43-45
dc.journal.pais
Alemania
dc.description.fil
Fil: Wang, Jing. Weill Cornell Medical College; Estados Unidos
dc.description.fil
Fil: Bains, Henrietta. Weill Cornell Medical College; Estados Unidos
dc.description.fil
Fil: Anastasia Gonzalez, Agustin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
dc.description.fil
Fil: Bracken, Clay. Weill Cornell Medical College; Estados Unidos
dc.journal.title
Biomolecular Nmr Assignments
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s12104-017-9777-0
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs12104-017-9777-0
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6865803/
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