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dc.contributor.author
Thoke, Henrik Seir
dc.contributor.author
Olsen, Lars F.
dc.contributor.author
Duelund, Lars
dc.contributor.author
Stock, R. P.
dc.contributor.author
Heimburg, Thomas
dc.contributor.author
Bagatolli, Luis Alberto
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dc.date.available
2020-02-07T18:06:43Z
dc.date.issued
2018-09
dc.identifier.citation
Thoke, Henrik Seir; Olsen, Lars F.; Duelund, Lars; Stock, R. P.; Heimburg, Thomas; et al.; Is a constant low-entropy process at the root of glycolytic oscillations?; Springer; Journal Of Biological Physics; 44; 3; 9-2018; 419-431
dc.identifier.issn
0092-0606
dc.identifier.uri
http://hdl.handle.net/11336/96876
dc.description.abstract
We measured temporal oscillations in thermodynamic variables such as temperature, heat flux, and cellular volume in suspensions of non-dividing yeast cells which exhibit temporal glycolytic oscillations. Oscillations in these variables have the same frequency as oscillations in the activity of intracellular metabolites, suggesting strong coupling between them. These results can be interpreted in light of a recently proposed theoretical formalism in which isentropic thermodynamic systems can display coupled oscillations in all extensive and intensive variables, reminiscent of adiabatic waves. This interpretation suggests that oscillations may be a consequence of the requirement of living cells for a constant low-entropy state while simultaneously performing biochemical transformations, i.e., remaining metabolically active. This hypothesis, which is in line with the view of the cellular interior as a highly structured and near equilibrium system where energy inputs can be low and sustain regular oscillatory regimes, calls into question the notion that metabolic processes are essentially dissipative.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ASSOCIATION-INDUCTION HYPOTHESIS
dc.subject
GLYCOLYTIC OSCILLATIONS
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ISENTROPIC PROCESS
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ONSAGER’S THEORY
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TEMPERATURE OSCILLATIONS
dc.subject.classification
Biofísica
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Is a constant low-entropy process at the root of glycolytic oscillations?
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-23T14:25:49Z
dc.identifier.eissn
1573-0689
dc.journal.volume
44
dc.journal.number
3
dc.journal.pagination
419-431
dc.journal.pais
Alemania
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dc.journal.ciudad
Berlin
dc.description.fil
Fil: Thoke, Henrik Seir. University of Southern Denmark; Dinamarca. International and Interdisciplinary Research Network; Dinamarca
dc.description.fil
Fil: Olsen, Lars F.. International and Interdisciplinary Research Network; Dinamarca. University of Southern Denmark; Dinamarca
dc.description.fil
Fil: Duelund, Lars. University of Southern Denmark; Dinamarca. International and Interdisciplinary Research Network; Dinamarca
dc.description.fil
Fil: Stock, R. P.. International and Interdisciplinary Research Network; Dinamarca
dc.description.fil
Fil: Heimburg, Thomas. Universidad de Copenhagen; Dinamarca
dc.description.fil
Fil: Bagatolli, Luis Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. International and Interdisciplinary Research Network; Dinamarca
dc.journal.title
Journal Of Biological Physics
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://link.springer.com/10.1007/s10867-018-9499-2
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s10867-018-9499-2
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