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dc.contributor.author
Ruiz, Paul
dc.contributor.author
Calliari, Aldo
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Genovese, Patricia
dc.contributor.author
Scorza, Cecilia
dc.contributor.author
Pautassi, Ricardo Marcos
dc.date.available
2020-02-07T18:04:42Z
dc.date.issued
2018-04
dc.identifier.citation
Ruiz, Paul; Calliari, Aldo; Genovese, Patricia; Scorza, Cecilia; Pautassi, Ricardo Marcos; Amphetamine, but not methylphenidate, increases ethanol intake in adolescent male, but not in female, rats; John Wiley & Sons Ltd; Brain and Behavior; 8; 4; 4-2018; 1-13
dc.identifier.issn
2162-3279
dc.identifier.uri
http://hdl.handle.net/11336/96867
dc.description.abstract
Introduction: There has been an increasing interest in analyzing the interactions between stimulants and ethanol during childhood and adolescence. Stimulants are used to treat attention-deficit hyperactivity disorder (ADHD) in these developmental stages, during which ethanol initiation and escalation often occur. Methods: This study assessed the effects of repeated d-amphetamine (AMPH) or methylphenidate (MPH) treatment during adolescence [male and female Wistar rats, between postnatal day (PD) 28 to PD34, approximately] on the initiation of ethanol intake during a later section of adolescence (PD35 to PD40). Results: Amphetamine and MPH exerted reliable acute motor stimulant effects, but there was no indication of sensitized motor or anxiety responses. MPH did not affect dopamine (DA) levels, whereas AMPH significantly reduced insular levels of DA in both sexes and norepinephrine levels in females only. Repeated treatment with AMPH, but not with MPH, enhanced ethanol intake during late adolescence in male, but not in female, rats. Conclusion: A short treatment with AMPH during adolescence significantly altered DA levels in the insula, both in male and females, and significantly enhanced ethanol intake in males. The present results suggest that, in adolescent males, a very brief history of AMPH exposure can facilitate the initiation of ethanol intake.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
John Wiley & Sons Ltd
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ADOLESCENCE
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AMPHETAMINE
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ETHANOL
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METHYLPHENIDATE
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MOTOR BEHAVIOR
dc.subject.classification
Drogadicción
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Amphetamine, but not methylphenidate, increases ethanol intake in adolescent male, but not in female, rats
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-23T14:26:19Z
dc.journal.volume
8
dc.journal.number
4
dc.journal.pagination
1-13
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Hoboken
dc.description.fil
Fil: Ruiz, Paul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Universidad de la República; Uruguay
dc.description.fil
Fil: Calliari, Aldo. Universidad de la República; Uruguay
dc.description.fil
Fil: Genovese, Patricia. Universidad de la República; Uruguay
dc.description.fil
Fil: Scorza, Cecilia. Instituto de Investigaciones Biológicas "Clemente Estable"; Uruguay
dc.description.fil
Fil: Pautassi, Ricardo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina
dc.journal.title
Brain and Behavior
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/brb3.939
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1002/brb3.939
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