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dc.contributor.author
Loney, Gregory C.
dc.contributor.author
Pautassi, Ricardo Marcos
dc.contributor.author
Kapadia, Delna
dc.contributor.author
Meyer, Paul J.
dc.date.available
2020-02-06T18:55:29Z
dc.date.issued
2018-09
dc.identifier.citation
Loney, Gregory C.; Pautassi, Ricardo Marcos; Kapadia, Delna; Meyer, Paul J.; Nicotine affects ethanol-conditioned taste, but not place, aversion in a simultaneous conditioning procedure; Elsevier Science Inc; Alcohol; 71; 9-2018; 47-55
dc.identifier.issn
0741-8329
dc.identifier.uri
http://hdl.handle.net/11336/96847
dc.description.abstract
The conditioned taste aversion (CTA) induced by ethanol is a key factor limiting ethanol intake. Nicotine, a drug co-consumed with ethanol, may decrease this aversion by modulating the unconditioned effects of ethanol or by disrupting the association between ethanol and its associated cues. This study analyzed ethanol-induced CTA and conditioned place aversion (CPA) in Long-Evans rats with subchronic exposure to nicotine. The rats were treated with nicotine (0.0 or 0.4 mg/kg) three times before conditioning (on lickometer training sessions 3, 4, and 5) and across conditioning days. During the conditioning the rats were given ethanol (1.3 g/kg) preceded and followed by presentation of a taste (NaCl) and tactile (rod or hole floors) conditioned stimulus (CS+), respectively. On CS− conditioning days, the rats were given vehicle and exposed to alternative stimuli. Three CTA and CPA testing sessions were then conducted. It was found that nicotine reduced ethanol-induced CTA and enhanced locomotor activity, but did not significantly modify the magnitude of ethanol-induced CPA. The effects of nicotine on CTA were observed during both conditioning and testing sessions, and were specific to the NaCl CS+, having no effect on reactivity to water. The dissociation between the effect of nicotine on ethanol-induced CTA and CPA suggests that nicotine does not alter ethanol's motivational properties by generally increasing its positive rewarding effects, nor does it blunt all aversive-like responses to this drug. Instead, nicotine may impede ethanol-induced CTA induced by ethanol by disrupting the neural underpinnings of this specific form of associative learning.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
ETHANOL
dc.subject
NICOTINE
dc.subject
PLACE AVERSION
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RAT
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SIMULTANEOUS CONDITIONING
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TASTE AVERSION
dc.subject.classification
Drogadicción
dc.subject.classification
Ciencias de la Salud
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Nicotine affects ethanol-conditioned taste, but not place, aversion in a simultaneous conditioning procedure
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-23T14:26:12Z
dc.journal.volume
71
dc.journal.pagination
47-55
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Loney, Gregory C.. State University of New York; Estados Unidos
dc.description.fil
Fil: Pautassi, Ricardo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
dc.description.fil
Fil: Kapadia, Delna. State University of New York; Estados Unidos
dc.description.fil
Fil: Meyer, Paul J.. State University of New York; Estados Unidos
dc.journal.title
Alcohol
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S074183291731011X
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.alcohol.2018.02.005
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109413/
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