Artículo
A key function for microtubule-associated-protein 6 in activity-dependent stabilisation of actin filaments in dendritic spines
Peris, Leticia; Bisbal, Mariano
; Martinez Hernandez, José; Saoudi, Yasmina; Jonckheere, Julie; Rolland, Marta; Sebastien, Muriel; Brocard, Jacques; Denarier, Eric; Bosc, Christopher; Guerin, Christophe; Gory Fauré, Sylvie; Deloulme, Jean Christophe; Lanté, Fabien; Arnal, Isabelle; Buisson, Alain; Goldberg, Yves; Blanchoin, Laurent; Delphin, Christian; Andrieux, Annie
Fecha de publicación:
12/2018
Editorial:
Nature Publishing Group
Revista:
Nature Communications
ISSN:
2041-1723
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Emerging evidence indicates that microtubule-associated proteins (MAPs) are implicated in synaptic function; in particular, mice deficient for MAP6 exhibit striking deficits in plasticity and cognition. How MAP6 connects to plasticity mechanisms is unclear. Here, we address the possible role of this protein in dendritic spines. We find that in MAP6-deficient cortical and hippocampal neurons, maintenance of mature spines is impaired, and can be restored by expressing a stretch of the MAP6 sequence called Mc modules. Mc modules directly bind actin filaments and mediate activity-dependent stabilisation of F-actin in dendritic spines, a key event of synaptic plasticity. In vitro, Mc modules enhance actin filament nucleation and promote the formation of stable, highly ordered filament bundles. Activity-induced phosphorylation of MAP6 likely controls its transfer to the spine cytoskeleton. These results provide a molecular explanation for the role of MAP6 in cognition, enlightening the connection between cytoskeletal dysfunction, synaptic impairment and neuropsychiatric illnesses.
Palabras clave:
Dendritic Spines
,
MAP6
,
Actin
,
Neurons
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(INIMEC - CONICET)
Articulos de INSTITUTO DE INV. MEDICAS MERCEDES Y MARTIN FERREYRA
Articulos de INSTITUTO DE INV. MEDICAS MERCEDES Y MARTIN FERREYRA
Citación
Peris, Leticia; Bisbal, Mariano; Martinez Hernandez, José; Saoudi, Yasmina; Jonckheere, Julie; et al.; A key function for microtubule-associated-protein 6 in activity-dependent stabilisation of actin filaments in dendritic spines; Nature Publishing Group; Nature Communications; 9; 1; 12-2018; 1-15
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